Age related changes in gut physiology and nutritional status.
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TLDR
Gastroenterologists should seek out and actively treat gastrointestinal disorders in the elderly and not just ascribe them to old age.Citations
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Gut microbiota composition correlates with diet and health in the elderly
Marcus J. Claesson,Ian B. Jeffery,Susana Conde,Susan E. Power,Eibhlís M. O'Connor,Siobhán Cusack,Hugh M. B. Harris,M. Coakley,Bhuvaneswari Lakshminarayanan,Orla O'Sullivan,Gerald F. Fitzgerald,Jennifer Deane,Michael O'Connor,Norma Harnedy,Kieran O'Connor,Denis O'Mahony,Denis O'Mahony,Douwe van Sinderen,Martina Wallace,Lorraine Brennan,Catherine Stanton,Catherine Stanton,Julian R. Marchesi,Anthony P. Fitzgerald,Fergus Shanahan,Colin Hill,R. Paul Ross,R. Paul Ross,Paul W. O'Toole +28 more
TL;DR: The data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.
Journal ArticleDOI
Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics
TL;DR: Inulin-derived oligosaccharides and GOS are mildly laxative, but can result in flatulence and osmotic diarrhoea if taken in large amounts.
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Characterization of Bacterial Communities in Feces from Healthy Elderly Volunteers and Hospitalized Elderly Patients by Using Real-Time PCR and Effects of Antibiotic Treatment on the Fecal Microbiota
TL;DR: The numbers of enterobacteria increased in the hospitalized patients who did not receive antibiotics, and due to profound changes in fecal microbiotas during antibiotic treatment, the opportunistic species Enterococcus faecalis proliferated.
Journal ArticleDOI
Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles
TL;DR: Polyphasic analysis of faecal bacteria showed that significant structural changes occur in the microbiota with aging, and this was especially evident with respect to putatively protective bifidobacteria.
Journal ArticleDOI
Amino acid ingestion improves muscle protein synthesis in the young and elderly
Douglas Paddon-Jones,Melinda Sheffield-Moore,Xiao-Jun Zhang,Elena Volpi,Steven E. Wolf,Asle Aarsland,Asle Aarsland,Arny A. Ferrando,Robert R. Wolfe,Robert R. Wolfe +9 more
TL;DR: Despite differences in the time course of plasma phenylalanine kinetics and a greater residual IC phenylAlanine concentration, amino acid supplementation acutely stimulated muscle protein synthesis in both young and elderly individuals.
References
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Journal ArticleDOI
Smell identification ability: changes with age
Richard L. Doty,Paul Shaman,Steven L. Applebaum,Ronita Giberson,Lenore Siksorski,Lysa Rosenberg +5 more
TL;DR: Smell identification ability was measured in 1955 persons ranging in age from 5 to 99 years and on the average, women outperformed men at all ages, and nonsmokers outperformed smokers.
Journal ArticleDOI
Effect of age on calcium absorption
TL;DR: Calcium absorption was measured by plasma radioactivity after oral calcium isotopes in seventy-five men and one hundred and fifteen women aged 20-95 years and everyone over 80 had significant malabsorption.
Journal ArticleDOI
Altered swallowing function in elderly patients without dysphagia: radiologic findings in 56 cases.
Olle Ekberg,Michael J. Feinberg +1 more
TL;DR: What has been described as swallowing dysfunction in young persons may not be abnormal in very elderly persons.
Journal ArticleDOI
Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women.
TL;DR: Assessment of the interrelationship among serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], calcium absorption and intestinal VDR in 44 healthy, ambulatory women found the data are far more consistent with impaired intestinal responsiveness to 1, 25-(OH), which could lead to compensatory increases in PTH secretion and 1-25-( OH)2 D3 production, but at the expense of increased bone loss.
Journal ArticleDOI
Studies of basal and peak acid output with an augmented histamine test
TL;DR: Both basal and maximum (histamine stimulated) gastric secretion declined with age, more so in women than in men, and in men than in women, especially in older subjects.
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Gut microbiota composition correlates with diet and health in the elderly
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