Journal ArticleDOI
Alkaline phosphatase: Structure, expression and its function in bone mineralization.
TLDR
The increased level of ALP expression and development in this environment would undoubtedly provide new and essential information about the fundamental molecular mechanisms of bone formation, offer therapeutic possibilities for the management of bone-related diseases.About:
This article is published in Gene.The article was published on 2020-09-05. It has received 263 citations till now. The article focuses on the topics: Pyrophosphate & Hypophosphatasia.read more
Citations
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3D-printed Mg-incorporated PCL-based scaffolds: A promising approach for bone healing.
Qiangsheng Dong,Ming Zhang,Xingxing Zhou,Yi Shao,Jiayi Li,Liming Wang,Chenglin Chu,Feng Xue,Qingqiang Yao,Jing Bai +9 more
TL;DR: Wang et al. as discussed by the authors developed 3D-printed customized Mg/PCL composite scaffolds with enhanced osteogenesis and biomineralization, which took a positive role in the improvement of biocompatibility and biodegradability.
Journal ArticleDOI
Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
TL;DR: In this paper, the effects of flavonoids have on the mitogen activated protein kinase (MAPK), nuclear factor kappa β (NF-kβ), Wnt/β-catenin, and bone morphogenetic protein 2/SMAD (BMP2/MAD) signalling pathways, and apoptotic pathways.
Journal ArticleDOI
Fabrication and Investigation of the Suitability of Chitosan-Silver Composite Scaffolds for Bone Tissue Engineering Applications
Baskaran Vaidhyanathan,Preethi Vincent,Sajini Vadivel,Ponmurugan Karuppiah,Naif Abdullah Al-Dhabi,Deepa Rani Sadhasivam,Selvaraj Vimalraj,Sekaran Saravanan +7 more
TL;DR: Biodegradable composite scaffolds were fabricated by utilizing CS and silver nanoparticles (AgNPs) were in-situ synthesised on CS matrix with no external reducing agent and CS-Ag 1.5 M scaffold was found to be superior and suitable for bone tissue engineering applications.
Journal ArticleDOI
Self-powered pulsed direct current stimulation system for enhancing osteogenesis in MC3T3-E1
Yingzi Zhang,Lingling Xu,Zhuo Liu,Zhuo Liu,Xi Cui,Zhuo Xiang,Zhuo Xiang,Jinyu Bai,Dongjie Jiang,Jiangtao Xue,Jiangtao Xue,Chan Wang,Youxi Lin,Zhe Li,Zhe Li,Yizhu Shan,Yuan Yang,Lin Bo,Zhou Li,Zhou Li,Xiaozhong Zhou +20 more
TL;DR: A biomechanical-energy-driven shape memory piezoelectric nanogenerator that integrated with fixation splint to promote osteogenic differentiation and shows great prospect self-powered and portable electronic medical device.
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Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair
TL;DR: These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue.
References
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Journal ArticleDOI
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Tripti Gaur,Christopher J. Lengner,Hayk Hovhannisyan,Ramesh A. Bhat,Peter V.N. Bodine,Barry S. Komm,Amjad Javed,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +10 more
TL;DR: It is proposed that WNT/TCF1 signaling, like bone morphogenetic protein/transforming growth factor-β signaling, activates Runx2 gene expression in mesenchymal cells for the control of osteoblast differentiation and skeletal development.
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The role of alkaline phosphatase in mineralization
TL;DR: The mechanism with which this enzyme carries out its function is not complete and it is appropriate to review the current status of this important enzyme.
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The mechanism of mineralization and the role of alkaline phosphatase in health and disease.
TL;DR: Although hypophosphatasia is untreatable at present, the recent success of enzyme replacement therapy offers promise, and strategies for preventing pathologic calcification using TNAP and NPP1 are in development.
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BMP signalling in skeletal development, disease and repair
TL;DR: The genetic evidence implicating BMP superfamily signalling in vertebrate bone and joint development is examined, a selection of human skeletal disorders associated with altered BMP signalling is discussed, and the status of modulating the BMP pathway as a therapeutic target for skeletal trauma and disease is summarized.
Journal ArticleDOI
The role of phosphatases in the initiation of skeletal mineralization.
TL;DR: It is shown that PHOSPHO1, a soluble phosphatase with specificity for two molecules present in MVs, phosphoethanolamine and phosphocholine, is responsible for initiating HA crystal formation inside MVs and that PHosPHO 1 and TNAP have nonredundant functional roles during endochondral ossification.