Journal ArticleDOI
All-inkjet-printed gold microelectrode arrays for extracellular recording of action potentials
Bernd Bachmann,Bernd Bachmann,Nouran Adly,Jan Schnitker,Alexey Yakushenko,Philipp Rinklin,Andreas Offenhäusser,Bernhard Wolfrum,Bernhard Wolfrum +8 more
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TLDR
In this article, the authors reported the fabrication of a disposable microelectrode array (MEA) using solely inkjet printing technology, which was fabricated with two different functional inks, a self-made gold ink to print conductive feedlines and electrodes and a polymer-based ink to add a dielectric layer for insulation of the feedlines.Abstract:
Inkjet printing is an attractive method for cost-effective additive manufacturing of electronic devices. Especially for applications where disposable sensor systems are of interest, it is a promising tool since it enables the production of low-cost and flexible devices. In this work, we report the fabrication of a disposable microelectrode array (MEA) using solely inkjet printing technology. The MEAs were fabricated with two different functional inks, a self-made gold ink to print conductive feedlines and electrodes and a polymer-based ink to add a dielectric layer for insulation of the feedlines. We printed different MEA designs of up to 64 electrodes with a minimum lateral spacing of 200 μm and a minimum electrode diameter of ~31 μm. As a proof-of-concept, extracellular recordings of action potentials from cardiomyocyte-like HL-1 cells were performed using the all-printed devices. Furthermore, we stimulated the cells during the recordings with noradrenaline, which led to an increase in the recorded beating frequency of the cells. The results demonstrate the feasibility of inkjet printing gold MEAs for cell-based bioelectronics.read more
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Conductive nanomaterials for 2D and 3D printed flexible electronics
TL;DR: This review describes recent developments in the field of conductive nanomaterials and their application in 2D and 3D printed flexible electronics, with particular emphasis on inks based on metal nanoparticles and nanowires, carbon nanotubes, and graphene sheets.
Journal ArticleDOI
High-throughput organ-on-a-chip systems: Current status and remaining challenges
TL;DR: The demands of modern-day HTS in drug discovery and development are introduced, the status-quo of parallelized OoC systems are reviewed, and the current limitation and remaining challenges that need to be overcome to increase the throughput of OoC experiments are discussed.
Journal ArticleDOI
Printed Microelectrode Arrays On Soft Materials: From PDMS to Hydrogels
Nouran Adly,Nouran Adly,Sabrina Weidlich,Silke Seyock,Fabian Brings,Alexey Yakushenko,Andreas Offenhäusser,Bernhard Wolfrum,Bernhard Wolfrum +8 more
TL;DR: A cost-effective and simple approach to make soft microelectrode arrays has been developed using inkjet printing of carbon-based conductive ink, which allows for rapid prototyping of disposable sensor array structures on various soft substrates for in vitro as well as in vivo applications.
Journal ArticleDOI
Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces.
Dzmitry Afanasenkau,Daria Kalinina,Vsevolod Lyakhovetskii,Christoph Tondera,Oleg Gorsky,Oleg Gorsky,Seyyed Moosavi,N. V. Pavlova,N. V. Pavlova,Natalia Merkulyeva,Natalia Merkulyeva,Allan V. Kalueff,Allan V. Kalueff,Ivan R. Minev,Ivan R. Minev,Pavel Musienko +15 more
TL;DR: It is shown that soft biocompatible materials can be rapidly printed for the on-demand prototyping of customized electrode arrays well adjusted to specific anatomical environments, functions and experimental models.
Journal ArticleDOI
Inkjet-printed PEDOT:PSS multi-electrode arrays for low-cost in vitro electrophysiology
Leonardo D. Garma,Laura M. Ferrari,Paola Scognamiglio,Francesco Greco,Francesco Greco,Francesca Santoro +5 more
TL;DR: The results validate the use of pMEAs as in vitro electrophysiology platforms, pushing for the adoption of innovative fabrication techniques and the useof new materials for the production of MEAs.
References
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Allen J. Bard,Larry R. Faulkner +1 more
TL;DR: In this paper, the authors present a comprehensive overview of electrode processes and their application in the field of chemical simulation, including potential sweep and potential sweep methods, coupled homogeneous chemical reactions, double-layer structure and adsorption.
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Capillary flow as the cause of ring stains from dried liquid drops
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Journal ArticleDOI
Size effect on the melting temperature of gold particles
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TL;DR: In this article, the melting points of small gold particles have been measured using a scanning electron-diffraction technique and the experimental results are quantitatively in good agreement with two phenomenological models.
Journal ArticleDOI
Inkjet Printing of Polymers: State of the Art and Future Developments
TL;DR: Inkjet printing is considered to be a key technology in the field of defined polymer deposition as mentioned in this paper, and a short overview of the available instrumentation is given, including manufacturing of multicolor polymer light-emitting diode displays, polymer electronics, three-dimensional printing, and oral dosage forms for controlled drug release.
Journal ArticleDOI
HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
William C. Claycomb,Nicholas A. Lanson,Beverly S. Stallworth,Daniel B. Egeland,Joseph B. Delcarpio,Anthony Bahinski,Nicholas J. Izzo +6 more
TL;DR: In this paper, the authors derived a cardiac muscle cell line, designated HL-1, from the AT-1 mouse atrial cardiomyocyte tumor lineage, which can be serially passaged, yet they maintain the ability to contract and retain differentiated cardiac morphological, biochemical, and electrophysiological properties.