Journal ArticleDOI
Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral Amygdala.
TLDR
In this paper , the effect of allopregnanolone on the basolateral amygdala (BLA) was investigated and it was shown that allop-regnanoline enhances the BLA high theta oscillations through δ-containing GABAA receptors.About:
This article is published in Biological Psychiatry.The article was published on 2022-02-01. It has received 18 citations till now. The article focuses on the topics: Allopregnanolone & Neuroactive steroid.read more
Citations
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Journal ArticleDOI
Zuranolone for the Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo-Controlled Phase 3 Trial.
Anita H. Clayton,Robert Lasser,Sagar V. Parikh,Dan V. Iosifescu,JungAh Jung,Mona Kotecha,Fiona Forrestal,Jeffrey M. Jonas,Stephen J. Kanes,James J. Doherty +9 more
TL;DR: In this article , the efficacy and safety of a 14-day treatment course of once-daily zuranolone 50 mg, an investigational oral positive allosteric modulator of the γ-aminobutyric acid type A (GABAA) receptor, for the treatment of major depressive disorder was evaluated.
Journal ArticleDOI
Preventing Phosphorylation of the GABAAR β3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids
TL;DR: In this paper , the authors used mice in which S408/9 in the β3 subunit have been mutated to alanines, mutations that prevent the metabotropic actions of NASs on GABAAR function while preserving NAS allosteric potentiation of GABAergic current.
Journal ArticleDOI
Brexanolone therapeutics in post-partum depression involves inhibition of systemic inflammatory pathways
Irina Balan,Riah Patterson,Giorgia Boero,Holly Krohn,Todd K. O'Buckley,Samantha Meltzer-Brody,A. Leslie Morrow +6 more
TL;DR: Brexanolone has shown promising results in the treatment of postpartum depression as discussed by the authors , which may promote clinical recovery by inhibiting proinflammatory modulators and macrophage activation.
Journal ArticleDOI
Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements
Irina Balan,Laure Aurelian,Kimberly S. Williams,Brian M. Campbell,Rick B. Meeker,A. Leslie Morrow +5 more
TL;DR: The results indicate that allopregnanolone inhibits TLR4 and TLR7 activation in cultured human macrophages resulting in diminished cytokine/chemokine production and suggest that inhibition of pro-inflammatory cytokines/chemicalokines may contribute to its therapeutic actions.
Journal ArticleDOI
Non-sedative cortical EEG signatures of allopregnanolone and functional comparators
Peter M. Lambert,Richard Ni,Ann Benz,Nicholas Rensing,Michael Wang,Charles F. Zorumski,Steven Mennerick +6 more
TL;DR: In this article , the EEG spectra during active exploration at two cortical locations and examined cross-regional and cross-frequency interactions of allopregnanolone and pentobarbital during active waking exploration.
References
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Journal ArticleDOI
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
TL;DR: Experimental analysis in the hippocampus and the neocortex and computational analysis suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators.
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Neuronal circuits for fear and anxiety
TL;DR: This Review focuses on studies that have used circuit-based approaches to gain a more detailed, and also more comprehensive and integrated, view on how the brain governs fear and anxiety and how it orchestrates adaptive defensive behaviours.
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Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors
TL;DR: It is reported that, at concentrations known to occur in vivo, neuroactive steroids specifically enhance a tonic inhibitory conductance in central neurons that is mediated by extrasynaptic δ subunit-containing GABAARs.
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Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors
TL;DR: The pharmacology of the stable cell line expressing human alpha(4)beta(3)delta GABA(A) receptor was investigated using whole-cell patch-clamp techniques as discussed by the authors.
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Extrasynaptic GABAA receptors: Their function in the CNS and implications for disease
Stephen G. Brickley,Istvan Mody +1 more
TL;DR: Extrasynaptic GABA(A) receptor populations that enable neurons to sense the low ambient GABA concentrations present in the extracellular space in order to generate a form of tonic inhibition not previously considered in studies of neuronal excitability present a therapeutic target for treatment of schizophrenia, epilepsy, and Parkinson's disease.