Journal ArticleDOI
Alpha-1-antitrypsin, autism, and cœliac disease
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This article is published in The Lancet.The article was published on 1972-10-21. It has received 553 citations till now. The article focuses on the topics: Alpha (ethology) & Autism.read more
Citations
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Response of intestinal mucosa to gluten challenge in autistic subjects
DenisM Mccarthy,Mary Coleman +1 more
TL;DR: The data suggest that the steatorrhoea and hypocalciuria seen in some autistic subjects cannot be accounted for by the presence of coeliac disease and patients should not be confined to gluten-free diets, unless rigorous behavioural studies demonstrate a statistically significant improvement in behaviour as a result of the diet, or deterioration during challenge.
Journal ArticleDOI
Meta‐analysis of clinical trials as a scientific discipline. I: Control of bias and comparison with large co‐operative trials
Thomas C. Chalmers,Howard R. Levin,Henry S. Sacks,Dinah Reitman,Jayne Berrier,Raguraman Nagalingam +5 more
TL;DR: Meta-analysis is an important method of bridging the gap between undersized randomized control trials and the treatment of patients, but the opportunities for bias to distort the results are widespread and attempts must be made to introduce the controls found in prospective studies.
Journal ArticleDOI
Autism and gastrointestinal symptoms
Karoly Horvath,Jay A. Perman +1 more
TL;DR: In children with autism, Mild to moderate degrees of inflammation were found in both the upper and lower intestinal tract and treatment of digestive problems appears to have positive effects on autistic behavior.
Journal ArticleDOI
Measuring the comparative efficacy of antibacterial agents for acute otitis media: the "Pollyanna phenomenon".
TL;DR: It is concluded that if efficacy is measured by symptomatic response, drugs with excellent antibacterial activity will appear less efficacious than they really are and drugs with poor antibacterial action will appear more efficacious.
Journal ArticleDOI
Clinical outcomes with β-blockers for myocardial infarction: a meta-analysis of randomized trials.
Sripal Bangalore,Harikrishna Makani,Martha J. Radford,Kamia Thakur,Bora Toklu,Stuart D. Katz,James J. DiNicolantonio,James J. DiNicolantonio,Philip J. Devereaux,Karen P. Alexander,Jørn Wetterslev,Franz H. Messerli +11 more
TL;DR: In this article, the authors conducted a MEDLINE/EMBASE/CENTRAL search for randomized trials evaluating β-blockers in myocardial infarction enrolling at least 100 patients.
References
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Journal Article
Manifestations of Immunologic Unresponsiveness in Hodgkin's Disease
TL;DR: It is suggested that the anergy of early Hodgkin's disease is a peripheral defect; a manifestation of abnormal lymphocyte function; this suggestion is supported by preliminary work with Hodgkins lymphocytes in vitro and following lymphocyte transfer.
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Zinc deficiency: effect on brain of the suckling rat.
TL;DR: Zinc deficiency has been showed to impair DNA and protein synthesis in brain of the suckling rat as it has previously been shown to do in other tissues including liver and epiphyseal plate.
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Symptomatic pulmonary emphysema in childhood associated with hereditary alpha-1-antitrypsin and elastase inhibitor deficiency.
Richard C. Talamo,Henry Levison,Matthew J. Lynch,Albert Hercz,Newton E. Hyslop,Harry W. Bain +5 more
TL;DR: Genetic studies of sera from 55 family members were performed by means of functional assays of elastase inhibition and total antitryptic activity and by measurements of alpha-1-antitrypsin concentration with a newly developed sensitive electroimmunodiffusion method.