Journal ArticleDOI
Alpha-1-antitrypsin, autism, and cœliac disease
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This article is published in The Lancet.The article was published on 1972-10-21. It has received 553 citations till now. The article focuses on the topics: Alpha (ethology) & Autism.read more
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The evaluation and management of acute otitis media in children
TL;DR: Some of the goals in managing pediatric AOM are to expediently resolve the acute episode, prevent recurrent episodes, hasten middle ear effusion (MEE) resolution, normalize and maintain normal hearing, and avoid any long-term impairment of speech, language, and cognitive development.
Book ChapterDOI
Secondary Amenorrhea and the Menopause
TL;DR: In the absence of pregnancy or lactation, it is surprising that secondary amenorrhea develops in so few women, and the presence of previously regular menses for 6 months or three menstrual cycles is defined as secondary amenorhea and warrants investigation.
Book ChapterDOI
The Hurler Cell in Culture
TL;DR: The establishment of permanent lymphoid Hurler lines having the same abnormal biochemical markers provides an alternate cell system for this research on the Hurler syndrome.
Journal ArticleDOI
Current Concepts of Therapy for Otitis Media.
TL;DR: This review highlights new developments in understanding of this complex interaction of the issues surrounding a physician’s decision to begin antibiotic therapy for acute otitis media.
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Journal Article
Manifestations of Immunologic Unresponsiveness in Hodgkin's Disease
TL;DR: It is suggested that the anergy of early Hodgkin's disease is a peripheral defect; a manifestation of abnormal lymphocyte function; this suggestion is supported by preliminary work with Hodgkins lymphocytes in vitro and following lymphocyte transfer.
Journal ArticleDOI
Zinc deficiency: effect on brain of the suckling rat.
TL;DR: Zinc deficiency has been showed to impair DNA and protein synthesis in brain of the suckling rat as it has previously been shown to do in other tissues including liver and epiphyseal plate.
Journal ArticleDOI
Symptomatic pulmonary emphysema in childhood associated with hereditary alpha-1-antitrypsin and elastase inhibitor deficiency.
Richard C. Talamo,Henry Levison,Matthew J. Lynch,Albert Hercz,Newton E. Hyslop,Harry W. Bain +5 more
TL;DR: Genetic studies of sera from 55 family members were performed by means of functional assays of elastase inhibition and total antitryptic activity and by measurements of alpha-1-antitrypsin concentration with a newly developed sensitive electroimmunodiffusion method.