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Alpha-1-antitrypsin, autism, and cœliac disease
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This article is published in The Lancet.The article was published on 1972-10-21. It has received 553 citations till now. The article focuses on the topics: Alpha (ethology) & Autism.read more
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5-Hydroxytryptamine receptor agonists for the abortive treatment of vascular headaches block mast cell, endothelial and platelet activation within the rat dura mater after trigeminal stimulation.
TL;DR: In this paper, the effects of pretreatment with dihydroergotamine and sumatriptan on the light and electron microscopic changes which develop after trigeminal ganglion stimulation were examined.
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Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity.
Alberto Falorni,Stefano Laureti,Paola Candeloro,Silvia Perrino,Concetta Coronella,Antonio Bizzarro,Antonio Bellastella,Fausto Santeusanio,Annamaria De Bellis +8 more
TL;DR: Markers of steroid-cell autoimmunity are found only rarely in idiopathic premature ovarian failure not associated with Addison disease, and 3beta-Hydroxysteroid dehydrogenase antibodies do not appear to be a major marker of steroids-cellautoantibodies.
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The Current Status of α-1-Antitrypsin, a Protease Inhibitor, in Gastrointestinal Disease
TL;DR: A glycoprotein with antigenic characteristics of α-1-antitrypsin (α1AT) is found in the endoplasmic reticulum of the hepatocytes of individuals with PiZ phenotype as discussed by the authors.
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Pia arachnoid contains substance P originating from trigeminal neurons.
TL;DR: Data indicate that most of the substance P surrounding pial blood vessels resides within afferent nerve fibres from trigeminal ganglion cells, similar to those found in peripheral structures receiving innervation from dorsal root or trigemINAL ganglia.
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Clustering and commonalities among autoimmune diseases.
TL;DR: Gene polymorphisms thus revealed include those that may determine tissue targeting particularly HLA alleles, the (numerous) genes that influence orderly progression among immune responses from innate immunity to effector processes, gene that influence pathways of apoptosis, and genes that Influence vulnerability of target organs to immune-mediated damage.
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Journal Article
Manifestations of Immunologic Unresponsiveness in Hodgkin's Disease
TL;DR: It is suggested that the anergy of early Hodgkin's disease is a peripheral defect; a manifestation of abnormal lymphocyte function; this suggestion is supported by preliminary work with Hodgkins lymphocytes in vitro and following lymphocyte transfer.
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Zinc deficiency: effect on brain of the suckling rat.
TL;DR: Zinc deficiency has been showed to impair DNA and protein synthesis in brain of the suckling rat as it has previously been shown to do in other tissues including liver and epiphyseal plate.
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Symptomatic pulmonary emphysema in childhood associated with hereditary alpha-1-antitrypsin and elastase inhibitor deficiency.
Richard C. Talamo,Henry Levison,Matthew J. Lynch,Albert Hercz,Newton E. Hyslop,Harry W. Bain +5 more
TL;DR: Genetic studies of sera from 55 family members were performed by means of functional assays of elastase inhibition and total antitryptic activity and by measurements of alpha-1-antitrypsin concentration with a newly developed sensitive electroimmunodiffusion method.