Journal ArticleDOI
Alterations of Emotional and Cognitive Behaviors in Matrix Metalloproteinase- 2 and -9-Deficient Mice~!2009-12-18~!2010-07-05~!2010-09-09~!
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This article is published in The Open Behavioral Science Journal.The article was published on 2010-09-09. It has received 17 citations till now. The article focuses on the topics: Matrix metalloproteinase.read more
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Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus
Hiroyuki Mizoguchi,Junya Nakade,Masaki Tachibana,Daisuke Ibi,Daisuke Ibi,Eiichi Someya,Hiroyuki Koike,Hiroyuki Kamei,Toshitaka Nabeshima,Shigeyoshi Itohara,Kazuhiro Takuma,Makoto Sawada,Jun Sato,Kiyofumi Yamada,Kiyofumi Yamada +14 more
TL;DR: MMP-9 is involved in the progression of behavioral phenotypes in kindled mice because of conversion of pro-BDNF to mature BDNF in the hippocampus, which is accompanied by decreased hippocampal levels of mature brain-derived neurotrophic factor.
Journal ArticleDOI
Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus.
TL;DR: The role of extracellular proteolysis in various aspects of synaptic plasticity in hippocampal mossy fiber synapses is reviewed, and a growing body of evidence demonstrates that among perisynaptic proteases, tissue plasminogen activator (tPA)/plasmin system, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and metalloproteinases play a crucial role in shaping plastic changes in this projection.
Journal ArticleDOI
Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment.
Kazuya Fukumoto,Hiroyuki Mizoguchi,Hideyuki Takeuchi,Hiroshi Horiuchi,Jun Kawanokuchi,Shijie Jin,Tetsuya Mizuno,Akio Suzumura +7 more
TL;DR: It is shown that oral administration of fingolimod ameliorated the impairment in object recognition memory and associative learning in mice injected with amyloid β and was associated with restoration of normal BDNF expression levels in the cerebral cortices and hippocampi, suggesting that neuroprotection was mediated by up-regulation of neuronal BDNF levels.
Journal ArticleDOI
Chronic Hyponatremia Causes Neurologic and Psychologic Impairments
Haruki Fujisawa,Yoshihisa Sugimura,Hiroshi Takagi,Hiroyuki Mizoguchi,Hideyuki Takeuchi,Hisakazu Izumida,Kohtaro Nakashima,Hiroshi Ochiai,Seiji Takeuchi,Atsushi Kiyota,Kazuya Fukumoto,Shintaro Iwama,Yoshiko Takagishi,Yoshitaka Hayashi,Hiroshi Arima,Yukio Komatsu,Yoshiharu Murata,Yutaka Oiso +17 more
TL;DR: The results suggest chronic hyponatremia in humans may cause gait disturbance and cognitive impairment, but these abnormalities are reversible and careful correction of this condition may improve quality of life and reduce mortality.
Journal ArticleDOI
Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9
Apostolia Fragkouli,Costas Papatheodoropoulos,Spiros Georgopoulos,Antonios Stamatakis,Fotini Stylianopoulou,Effie C. Tsilibary,Athina K. Tzinia +6 more
TL;DR: In this paper, the in vivo role of matrix metalloproteinase 9 (MMP9) enzymatic activity in synaptic plasticity and cognitive processes was investigated in transgenic mice.
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