Journal ArticleDOI
American Thyroid Association Guidelines on the Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of Encapsulated Follicular Variant Papillary Thyroid Carcinoma Without Invasion to Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features
Bryan R. Haugen,Anna M. Sawka,Erik K. Alexander,Keith C. Bible,Patrizio Caturegli,Gerard M. Doherty,Susan J. Mandel,John C. Morris,Aziza Nassar,Furio Pacini,Martin Schlumberger,Kathryn G. Schuff,Steven I. Sherman,Hilary Somerset,Julie Ann Sosa,David L. Steward,Leonard Wartofsky,Michelle D. Williams +17 more
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TLDR
It is recommended that the histopathologic nomenclature for eFVPTC without invasion be reclassified as a NIFTP, given the excellent prognosis of this neoplastic variant.Abstract:
American Thyroid Association (ATA) leadership asked the ATA Thyroid Nodules and Differentiated Thyroid Cancer Guidelines Task Force to review, comment on, and make recommendations related to the suggested new classification of encapsulated follicular variant papillary thyroid carcinoma (eFVPTC) without capsular or vascular invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). The task force consists of members from the 2015 guidelines task force with the recusal of three members who were authors on the paper under review. Four pathologists and one endocrinologist were added for this specific review. The manuscript proposing the new classification and related literature were assessed. It is recommended that the histopathologic nomenclature for eFVPTC without invasion be reclassified as a NIFTP, given the excellent prognosis of this neoplastic variant. This is a weak recommendation based on moderate-quality evidence. It is also noted that prospective studies are n...read more
Citations
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Journal ArticleDOI
The Diagnosis and Management of Thyroid Nodules: A Review
Cosimo Durante,Giorgio Grani,Livia Lamartina,Sebastiano Filetti,Susan J. Mandel,David S. Cooper +5 more
TL;DR: A diagnostic approach that uses ultrasound and, when indicated, fine-needle aspiration biopsy and molecular testing, facilitates a personalized, risk-based protocol that promotes high-quality care and minimizes cost and unnecessary testing.
Journal ArticleDOI
Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study.
David L. Steward,Sally E. Carty,Rebecca S. Sippel,Samantha Peiling Yang,Julie Ann Sosa,Julie Ann Sosa,Jennifer A. Sipos,James J Figge,Susan J. Mandel,Bryan R. Haugen,Kenneth D. Burman,Zubair W. Baloch,Ricardo V. Lloyd,Raja R. Seethala,William E. Gooding,Simion I. Chiosea,Cristiane Gomes-Lima,Robert L. Ferris,Jessica M. Folek,Raheela Khawaja,Priya Kundra,Kwok Seng Loh,Carrie Marshall,Sarah E. Mayson,Kelly L. McCoy,Min En Nga,Kee Yuan Ngiam,Marina N. Nikiforova,Jennifer L. Poehls,Matthew D. Ringel,Huaitao Yang,Linwah Yip,Yuri E. Nikiforov +32 more
TL;DR: In this prospective, blinded, multicenter study, the multigene GC test demonstrated a high sensitivity/NPV and reasonably high specificity/PPV, which may obviate diagnostic surgery in up to 61% of patients with Bethesda III to IV indeterminate nodules, and up to 82% of all benign nodules with indeterminates cytology.
Journal ArticleDOI
Clinical Safety of Renaming Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: Is NIFTP Truly Benign?
David N. Parente,Wouter P. Kluijfhout,Pim J. Bongers,Raoul Verzijl,Karen Devon,Lorne Rotstein,David P. Goldstein,Sylvia L. Asa,Ozgur Mete,Jesse D. Pasternak +9 more
TL;DR: Although the authors fully support the de-escalation of aggressive treatment for low-risk thyroid cancers, NIFTP behaves as a low- risk thyroid cancer rather than a benign entity and ongoing surveillance is warranted.
Journal ArticleDOI
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a review for pathologists
Raja R. Seethala,Zubair W. Baloch,Justine A. Barletta,Elham Khanafshar,Ozgur Mete,Peter M. Sadow,Virginia A. LiVolsi,Yuri E. Nikiforov,Giovanni Tallini,Lester D.R. Thompson +9 more
TL;DR: This monograph is a synopsis and guide for pathologists on NIFTP and focuses on histologic features, including inclusion and exclusion criteria used to define NifTP, as well as grossing guidelines, reporting practices, and potential diagnostic limitations.
Journal ArticleDOI
Afirma Gene Sequencing Classifier Compared with Gene Expression Classifier in Indeterminate Thyroid Nodules.
Mayumi Endo,Fadi Nabhan,Kyle Porter,Katie Roll,Lawrence A. Shirley,Irina Azaryan,Dena Tonkovich,Jeanette Perlick,Laura E. Ryan,Raheela Khawaja,Shumei Meng,John E. Phay,Matthew D. Ringel,Jennifer A. Sipos +13 more
TL;DR: Data from a single academic tertiary center shows an improved specificity and PPV while maintaining high sensitivity and NPV for GSC compared to GEC, likely indicating fewer false positive results.
References
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Journal ArticleDOI
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Bryan R. Haugen,Erik K. Alexander,Keith C. Bible,Gerard M. Doherty,Susan J. Mandel,Yuri E. Nikiforov,Furio Pacini,Gregory W. Randolph,Anna M. Sawka,Martin Schlumberger,Kathryn G. Schuff,Steven I. Sherman,Julie Ann Sosa,David L. Steward,R. Michael Tuttle,Leonard Wartofsky +15 more
TL;DR: Evidence-based recommendations are developed to inform clinical decision-making in the management of thyroid nodules and differentiated thyroid cancer and represent, in the authors' opinion, contemporary optimal care for patients with these disorders.
Journal ArticleDOI
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors
Yuri E. Nikiforov,Raja R. Seethala,Giovanni Tallini,Zubair W. Baloch,Fulvio Basolo,Lester D.R. Thompson,Justine A. Barletta,Bruce M. Wenig,Abir Al Ghuzlan,Kennichi Kakudo,Thomas J. Giordano,Venancio Avancini Ferreira Alves,Elham Khanafshar,Sylvia L. Asa,Adel K. El-Naggar,William E. Gooding,Steven P. Hodak,Ricardo V. Lloyd,Guy Maytal,Ozgur Mete,Marina N. Nikiforova,Vania Nosé,Mauro Papotti,David N. Poller,Peter M. Sadow,Arthur S. Tischler,R. Michael Tuttle,Kathryn B. Wall,Virginia A. LiVolsi,Gregory W. Randolph,Ronald Ghossein +30 more
TL;DR: Thyroid tumors currently diagnosed as noninvasive EFVPTC have a very low risk of adverse outcome and should be termed NIFTP, and this reclassification will affect a large population of patients worldwide and result in a significant reduction in psychological and clinical consequences associated with the diagnosis of cancer.
Journal ArticleDOI
Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference.
Zubair W. Baloch,Virginia A. LiVolsi,Syl L. Asa M.D.,Juan Rosai,Maria J. Merino,Gregory Randolph,Philippe Vielh,Richard M. DeMay,Mary K. Sidawy,William J. Frable +9 more
TL;DR: This document summarizes matters regarding diagnostic terminology/classification scheme for thyroid FNA interpretation and cytomorphologic criteria for the diagnosis of various benign and malignant thyroid lesions.
Journal ArticleDOI
Impact of reclassifying noninvasive follicular variant of papillary thyroid carcinoma on the risk of malignancy in the Bethesda System for Reporting Thyroid Cytopathology
William C. Faquin,Lawrence Q. Wong,A. Afrogheh,Syed Z. Ali,Justin A. Bishop,Massimo Bongiovanni,Marc Pusztaszeri,Christopher J. VandenBussche,Jolanta Gourmaud,Louis J. Vaickus,Zubair W. Baloch +10 more
TL;DR: This study assesses the potential impact of a reclassification of papillary thyroid carcinoma as a neoplasm rather than a carcinoma on the implied risk of malignancy for the diagnostic categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).
Journal ArticleDOI
The Impact of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma on Rates of Malignancy for Fine-Needle Aspiration Diagnostic Categories
Kyle C. Strickland,Brooke E. Howitt,Ellen Marqusee,Erik K. Alexander,Edmund S. Cibas,Jeffrey F. Krane,Justine A. Barletta +6 more
TL;DR: If terminology were changed and NFVPTCs were not considered carcinomas, the rates of malignancy for FNA diagnostic categories would be substantially decreased, with the most clinically significant decrease seen in the SUS category, which demonstrated a relative decrease of nearly 50%.
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