Journal ArticleDOI
An ACTH receptor on human mononuclear leukocytes. Relation to adrenal ACTH-receptor activity.
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TLDR
The inaccessibility of many tissues makes routine investigation for receptor defects impossible, and reports of ACTH insensitivity syndrome, first described by Shepard et al.1 in 1959 and now reported in more than 50 studies, suggest this.Abstract:
THE inaccessibility of many tissues makes routine investigation for receptor defects impossible. ACTH insensitivity syndrome, first described by Shepard et al.1 in 1959 and now reported in more tha...read more
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The syntax of immune-neuroendocrine communication
TL;DR: Edwin Blalock discusses how these shared ligands and receptors are used as a common chemical language for communication within and between the immune and neuroendocrine systems, suggesting an immunoregulatory role for the brain and a sensory function for the immune system.
Journal ArticleDOI
Adrenocorticotropin Insensitivity Syndromes
Adrian J. L. Clark,A. Weber +1 more
TL;DR: The pancreas-based treatment for triple A syndrome and the discovery of acquired ACTH Resistance are described in detail in the second part of this monograph.
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Psychoneuroimmunology: stress effects on pathogenesis and immunity during infection.
TL;DR: Recent psychoneuroimmunology literature exploring the effects of stress on the pathogenesis of, and immune response to, infectious disease in mammals is reviewed.
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The immune system as the sixth sense
TL;DR: This review will discuss some of the pivotal results that deciphered this chemical language that the nervous and immune systems produce a common set of peptide and nonpeptide neurotransmitters and cytokines that act on a common repertoire of receptors in the two systems.
Journal ArticleDOI
Antibiotic proteins of polymorphonuclear leukocytes
TL;DR: The polymorphonuclear leukocyte plays an essential role in the innate defense of the mammalian host against bacterial invaders and an array of antimicrobial proteins and peptides directed at microorganisms both before and after sequestration into a phagocytic vacuole.
References
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Journal ArticleDOI
A graphic method for the determination and presentation of binding parameters in a complex system
TL;DR: A graphic method is presented which correlates on a single graph the physicochemical parameters of a binding system consisting of one ligand and one or more binding macromolecules each having one ormore groups of mutually noninteracting binding sites.
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Histamine catabolism in male and female mice, guinea-pigs and rabbits.
TL;DR: The percentage urinary excretion of radioactive Histamine after a subcutaneous injection of radioactive histamine was about the same in both sexes in mice, guinea-pigs and rabbits, but varied bet...
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Familial glucocorticoid deficiency with achalasia of the cardia and deficient tear production.
TL;DR: Isolated glucocorticoid failure associated with achalasia of the cardia is described in two pairs of siblings in separate families, which probably represents a familial disorder of as yet unknown aetiology.
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Regulation of the in vitro antibody response by neuroendocrine hormones
TL;DR: The data show that neuroendocrine polypeptide hormones can regulate the immune response and include ACTH and alpha-endorphin, which had similar suppression properties; thus, the hormone-like activities associated with IFN-alpha may play a role inIFN-induced immunosuppression.
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Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon
E M Smith,J E Blalock +1 more
TL;DR: Almost 100% of the human peripheral lymphocytes were capable of producing both ACTH and gamma-endorphin-related substances, presumably associated with hIFN-alpha, which strongly suggest a circuit between the immune and neuroendocrine systems which involves neuroendocrin hormone-like substances.