An Anatomically Detailed Arterial Network Model for One-Dimensional Computational Hemodynamics
Pablo J. Blanco,Sansuke M. Watanabe,Marco Aurelio R. F. Passos,Pedro A. Lemos,Raúl A. Feijóo +4 more
TLDR
The present model features excellent descriptive and predictive capabilities in both patient-generic and patient-specific cases, presenting a new step toward integrating an unprecedented anatomical description, morphometric, and simulations data to help in understanding complex arterial blood flow phenomena and related cardiovascular diseases.Abstract:
Simulation platforms are increasingly becoming complementary tools for cutting-edge cardiovascular research. The interplay among structural properties of the arterial wall, morphometry, anatomy, wave propagation phenomena, and ultimately, cardiovascular diseases continues to be poorly understood. Accurate models are powerful tools to shed light on these open problems. We developed an anatomically detailed computational model of the arterial vasculature to conduct 1-D blood flow simulations to serve as simulation infrastructure to aid cardiovascular research. An average arterial vasculature of a man was outlined in 3-D space to serve as geometrical substrate for the mathematical model. The architecture of this model comprises almost every arterial vessel acknowledged in the medical/anatomical literature, with a resolution down to the luminal area of perforator arteries. Over 2000 arterial vessels compose the model. Anatomical, physiological, and mechanical considerations were employed for the set up of model parameters and to determine criteria for blood flow distribution. Computational fluid dynamics was used to simulate blood flow and wave propagation phenomena in such arterial network. A sensitivity analysis was developed to unveil the contributions of model parameters to the conformation of the pressure waveforms. In addition, parameters were modified to target model to a patient-specific scenario. On the light of the knowledge domain, we conclude that the present model features excellent descriptive and predictive capabilities in both patient-generic and patient-specific cases, presenting a new step toward integrating an unprecedented anatomical description, morphometric, and simulations data to help in understanding complex arterial blood flow phenomena and related cardiovascular diseases.read more
Citations
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Integrated Heart—Coupling multiscale and multiphysics models for the simulation of the cardiac function
Alfio Quarteroni,Alfio Quarteroni,Toni Lassila,Toni Lassila,Simone Rossi,Simone Rossi,Ricardo Ruiz-Baier,Ricardo Ruiz-Baier +7 more
TL;DR: This article addresses the numerical modeling of many aspects of heart function, including the interaction of the cardiac electrophysiology system with contractile muscle tissue, the sub-cellular activation–contraction mechanisms, as well as the hemodynamics inside the heart chambers.
Journal ArticleDOI
One-Dimensional Haemodynamic Modeling and Wave Dynamics in the Entire Adult Circulation
TL;DR: The model will be an important resource for studying the mechanics underlying pressure/flow waveforms throughout the circulation, along with global interactions between the heart and vessels under normal and pathological conditions.
Journal ArticleDOI
The cardiovascular system: Mathematical modelling, numerical algorithms and clinical applications *
TL;DR: This review article will address the two principal components of the cardiovascular system: arterial circulation and heart function, and systematically describe all aspects of the problem, ranging from data imaging acquisition to the development of reduced-order models that are of paramount importance when solving problems with high complexity, which would otherwise be out of reach.
Journal ArticleDOI
Geometric multiscale modeling of the cardiovascular system, between theory and practice
TL;DR: This review paper addresses the so called geometric multiscale approach for the numerical simulation of blood flow problems, from its origin (that the authors can collocate in the second half of '90s) to their days, and details the most popular numerical algorithms for the solution of the coupled problems.
Journal ArticleDOI
A benchmark study of numerical schemes for one‐dimensional arterial blood flow modelling
Etienne Boileau,Perumal Nithiarasu,Pablo J. Blanco,Pablo J. Blanco,Lucas O. Müller,Lucas O. Müller,Fredrik Eikeland Fossan,Leif Rune Hellevik,WP Wouter Donders,Wouter Huberts,Marie Willemet,Jordi Alastruey +11 more
TL;DR: A systematic comparison of six commonly used numerical schemes for 1D’sblood flow modelling, showing a good agreement among all numerical schemes and their ability to capture the main features of pressure, flow and area waveforms in large arteries.
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