An automated maze task for assessing hippocampus-sensitive memory in mice
Elsa Y. Pioli,Elsa Y. Pioli,Brianna N. Gaskill,Gary Gilmour,Mark D. Tricklebank,Sophie Dix,David M. Bannerman,Joseph P. Garner +7 more
TLDR
An automated maze was developed for assessing alternation performance in mice and Alternation performance was shown to be impaired in mice with lesions to the hippocampus.About:
This article is published in Behavioural Brain Research.The article was published on 2014-03-15 and is currently open access. It has received 36 citations till now.read more
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The significance of meaning: why do over 90% of behavioral neuroscience results fail to translate to humans, and what can we do to fix it?
TL;DR: This review argues that the philosophy and practice of experimental design and analysis is so different in basic animal work and human clinical trials that an animal experiment cannot reasonably predict the outcome of a human trial, and advocates a fundamental shift.
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Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model
Ashleigh L. Osborne,Nadia Solowij,Ilijana Babic,Ilijana Babic,Xu-Feng Huang,Xu-Feng Huang,Katrina Weston-Green,Katrina Weston-Green +7 more
TL;DR: Chronic CBD administration can attenuate the social interaction and cognitive deficits induced by prenatal poly I:C infection, and present interesting implications for potential use of CBD in treating the cognitive deficits and social withdrawal of schizophrenia.
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Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage.
Vootele Voikar,Vootele Voikar,Sven Krackow,Hans-Peter Lipp,Hans-Peter Lipp,Anton Rau,Anton Rau,Giovanni Colacicco,David P. Wolfer,David P. Wolfer +9 more
TL;DR: The results corroborate the view that hippocampal dysfunction spares simple spatial learning tasks but impairs the ability to cope with conflicting task‐inherent spatial, temporal or emotional cues.
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From Systemic Inflammation to Neuroinflammation: The Case of Neurolupus.
TL;DR: The underlying mechanisms explaining how systemic inflammation can result in behavioral deficits are explored, with a special focus on in vivo neuroimaging techniques.
References
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Précis of The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-Hippocampal System..
TL;DR: It is proposed that these drugs reduce anxiety by impairing the functioning of a widespread neural system including the septo-hippocampal system (SHS), the Papez circuit, the prefrontal cortex, and ascending monoaminergic and cholinergic pathways which innervate these forebrain structures.
Journal ArticleDOI
Unbiased stereological estimation of the number of neurons in the human hippocampus
TL;DR: The total numbers of neurons in five subdivisions of human hippocampi were estimated using unbiased Stereological principles and systematic sampling techniques to address the problems associated with the results and conclusions of previous quantitative studies.
Journal ArticleDOI
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
Paul F. Chapman,Gail L. White,Matt Jones,Deirdre Cooper-Blacketer,Vanessa J. Marshall,Michael C. Irizarry,Linda H. Younkin,Mark Andrew Good,Timothy V. P. Bliss,Bradley T. Hyman,Steven G. Younkin,Karen K. Hsiao +11 more
TL;DR: Impairments in functional synaptic plasticity may underlie some of the cognitive deficits in these mice and, possibly, in Alzheimer's patients.
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Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias
TL;DR: The fundamental differences between the newer design-based counting techniques and previously available assumption-based techniques are described, and the distinction between an unbiased estimate and a precise estimate is described.
Book
Modern statistics for the life sciences
Alan Grafen,Rosemary Hails +1 more
TL;DR: In this paper, the authors present an introduction to the analysis of variance and the meaning of p-values and confidence intervals, as well as results about variances of sample means.