Journal ArticleDOI
An efficient synthesis of pyrimido[4,5‐b]quinoline derivatives via three‐component reaction in aqueous media
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This article is published in Journal of Heterocyclic Chemistry.The article was published on 2009-03-01. It has received 30 citations till now. The article focuses on the topics: Quinoline.read more
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Efficient one-pot synthesis of spirooxindole derivatives catalyzed by L-proline in aqueous medium.
TL;DR: An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported.
Journal ArticleDOI
L-Proline-promoted three-component reaction of anilines, aldehydes and barbituric acids/malononitrile: regioselective synthesis of 5-arylpyrimido[4,5-b]quinoline-diones and 2-amino-4-arylquinoline-3-carbonitriles in water
TL;DR: A green and efficient one-pot process to achieve 5-aryl-pyrimido[4,5-b]quinoline-dione derivatives, using a three-component reaction involving anilines, aldehydes and barbituric acids was developed in this article.
Journal ArticleDOI
Water as the reaction medium for multicomponent reactions based on boronic acids
Nuno R. Candeias,Pedro M. S. D. Cal,Vânia André,M. Teresa Duarte,Luis F. Veiros,Pedro M. P. Gois +5 more
TL;DR: An efficient one-pot method for the assembly of boron-heterocycles based on amino-acids, boronic acids and salicylaldehyde using water as the reaction media is presented in this paper.
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Synthesis of heterocyclic scaffolds through 6-aminouracil-involved multicomponent reactions
TL;DR: The use of 6-aminouracil as a starting material in the synthesis of various heterocyclic structures such as pyrido-, pyrrolo-, and pyrimido-pyrimidines, fused spirooxindole derivatives, etc. as discussed by the authors.
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Recent Advances on Diversity Oriented Heterocycle Synthesis of Fused Quinolines and Its Biological Evaluation
TL;DR: In this article, quinoline derivatives have been shown to be useful starting materials and building blocks for the synthesis of a great variety of functionalized polynuclear heterocyclic syst...
References
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Asymmetric multicomponent reactions (amcrs): the new frontier
Diego J. Ramón,Miguel Yus +1 more
TL;DR: Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously and has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects.
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Organic reactions in aqueous media - with a focus on carbon-carbon bond formation
TL;DR: In the last decade, there has been increasing recognition that organic reactions carried out in aqueous media may offer advantages over those occurring in organic solvents as discussed by the authors, which is the essence of organic synthesis.
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Recent Developments in the Isonitrile‐Based Multicomponent Synthesis of Heterocycles
TL;DR: A review of isocyanide-based multicomponent reactions for heterocycle synthesis can be found in this paper, where the authors advocate a "substrate-design approach" in searching for novel MCRs.
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Molecular targets for AIDS therapy
TL;DR: In the future, non-nucleoside-type drugs will likely become more important in the experimental therapy of AIDS, and antiretroviral therapy will exert major effects against the morbidity and mortality caused by HIV.
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Strategies for heterocyclic construction via novel multicomponent reactions based on isocyanides and nucleophilic carbenes.
Vijay Nair,C. Rajesh,A. U. Vinod,S. Bindu,A. R. Sreekanth,Joseph Swaroop Mathen,Lakshmi Balagopal +6 more
TL;DR: The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance and encompass the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles.