An Electroreductive Approach to Radical Silylation via the Activation of Strong Si-Cl Bond.
TLDR
This work presents a new strategy for silyl radical generation via electroreduction of readily available chlorosilanes through energetically uphill reductive cleavage of strong Si-Cl bonds, which proved to be general in various alkene silylation reactions including disilylation, hydrosilylated, and allylic silylated under simple and transition-metal-free conditions.Abstract:
The construction of C(sp3)-Si bonds is important in synthetic, medicinal, and materials chemistry. In this context, reactions mediated by silyl radicals have become increasingly attractive but methods for accessing these intermediates remain limited. We present a new strategy for silyl radical generation via electroreduction of readily available chlorosilanes. At highly biased potentials, electrochemistry grants access to silyl radicals through energetically uphill reductive cleavage of strong Si-Cl bonds. This strategy proved to be general in various alkene silylation reactions including disilylation, hydrosilylation, and allylic silylation under simple and transition-metal-free conditions.read more
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References
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Journal ArticleDOI
Organosilicon Molecules with Medicinal Applications
TL;DR: Applications such as inhibitor design, imaging, drug release technology, and mapping inhibitor binding are discussed.
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Earth-Abundant Transition Metal Catalysts for Alkene Hydrosilylation and Hydroboration: Opportunities and Assessments.
TL;DR: Transition-metal-catalysed hydrosilylation and hydroboration reactions are valuable in the synthesis of commodity and fine chemicals, respectively and the catalyst design principles that enable us to perform these reactions using catalysts based on earth-abundant metals are described.
Journal ArticleDOI
Recent advances and actual challenges in late transition metal catalyzed hydrosilylation of olefins from an industrial point of view
Dennis Troegel,Jürgen Stohrer +1 more
TL;DR: In this article, the key catalytic reaction for the production of organosilicon compounds, such as organofunctional silanes and silicones, is used for crosslinking of silicone polymers to elastomers and silicone-based release coatings, and for coupling of silane and siloxanes to organic polymers.