Journal ArticleDOI
An immunomodulatory polysaccharide‐rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity
Anne Hirazumi,Eiichi Furusawa +1 more
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Improved survival time and curative effects occurred when noni‐ppt was combined with sub‐optimal doses of the standard chemotherapeutic agents, adriamycin (Adria), cisplatin (CDDP), 5‐fluorouracil (5‐FU), and vincristine (VCR), suggesting important clinical applications of noni-ppt as a supplemental agent in cancer treatment.Abstract:
The fruit juice of Morinda citrifolia (noni) contains a polysaccharide-rich substance (noni-ppt) with antitumour activity in the Lewis lung (LLC) peritoneal carcinomatosis model. Therapeutic administration of noni-ppt significantly enhanced the duration of survival of inbred syngeneic LLC tumour bearing mice. It did not exert significant cytotoxic effects in an adapted culture of LLC cells, LLC1, but could activate peritoneal exudate cells (PEC) to impart profound toxicity when co-cultured with the tumour cells. This suggested the possibility that noni-ppt may suppress tumour growth through activation of the host immune system. Concomitant treatment with the immunosuppressive agent, 2-chloroadenosine (C1-Ade) or cyclosporin (cys-A) diminished its activity, thereby substantiating an immunomodulatory mechanism. Noni-ppt was also capable of stimulating the release of several mediators from murine effector cells, including tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-10, IL-12 p70, interferon-gamma (IFN-gamma) and nitric oxide (NO), but had no effect on IL-2 and suppressed IL-4 release. Improved survival time and curative effects occurred when noni-ppt was combined with sub-optimal doses of the standard chemotherapeutic agents, adriamycin (Adria), cisplatin (CDDP), 5-fluorouracil (5-FU), and vincristine (VCR), suggesting important clinical applications of noni-ppt as a supplemental agent in cancer treatment.read more
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Botanical polysaccharides: macrophage immunomodulation and therapeutic potential.
Igor A. Schepetkin,Mark T. Quinn +1 more
TL;DR: The evaluation of botanical polysaccharide isolated from a wide array of different species of flora provides a unique opportunity for the discovery of novel therapeutic agents and adjuvants that exhibit beneficial immunomodulatory properties.
Journal Article
Morinda citrifolia (Noni): a literature review and recent advances in Noni research.
Mian Ying Wang,Brett J. West,C. Jarakae Jensen,Diane Nowicki,Chen Su,Afa Kehaati Palu,Gary Anderson +6 more
TL;DR: The nutritional and medicinal value of the Noni plant is revealed, scientific evidence that supports the Polynesians' claim is summarized, and a literature review and recent advances in Noni research are given.
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Bioactivities, bioactive compounds and chemical constituents of mangrove plants
TL;DR: The traditional and medicinal uses, and recent investigations on the biological activities of extracts, and chemicals identified from mangroves and mangal associates are examined.
Journal ArticleDOI
The noni fruit (Morinda citrifolia L.) : A review of agricultural research, nutritional and therapeutic properties
Yanine Chan-Blanco,Fabrice Vaillant,Ana Mercedes Pérez,Max Reynes,Jean-Marc Brillouet,Pierre Brat +5 more
TL;DR: If, in the future, the nutritional and medical values of the noni can be assessed, especially its anti-cancer activity, this fruit could play a noticeable economic role in producing countries.
Journal ArticleDOI
Biosynthesis, characterization and cytotoxic effect of plant mediated silver nanoparticles using Morinda citrifolia root extract.
TL;DR: These biologically synthesized nanoparticles were proved to exhibit excellent cytotoxic effect on HeLa cell and the X-ray diffraction spectrum XRD pattern clearly indicates that the silver nanoparticles formed in the present synthesis were crystalline in nature.
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