Journal ArticleDOI
An in vivo method for the quantitative evaluation of local anesthetics
TLDR
A mouse model for evaluation of skin anesthesia after infiltration of local anesthetic, and monitoring the vocalization response to electrical stimulus as a measure of analgesia, which is sufficiently sensitive to detect differences between the dose and duration of local anesthesia is described.About:
This article is published in Journal of Pharmacological and Toxicological Methods.The article was published on 2000-02-01. It has received 29 citations till now. The article focuses on the topics: Chloroprocaine & Anesthetic.read more
Citations
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Journal ArticleDOI
A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
TL;DR: A protocol and a movie describing a straightforward surgical technique, which takes 15–20 min, to consistently remove two-thirds of the liver in mice are provided and it is hoped that it will be widely used and serve to standardize 2/3 PH in mice.
Journal ArticleDOI
A Novel Liposomal Bupivacaine Formulation to Produce Ultralong-Acting Analgesia
Gilbert J. Grant,Yechezkel Barenholz,Elijah M. Bolotin,Mylarrao Bansinath,Herman Turndorf,Boris Piskoun,Elyad M. Davidson +6 more
TL;DR: This novel liposomal formulation had a favorable drug-to-phospholipid ratio and prolonged the duration of bupivacaine analgesia in a dose-dependent manner and has the potential to significantly impact the management of pain.
Journal ArticleDOI
DRV Liposomal Bupivacaine: Preparation, Characterization, and In Vivo Evaluation in Mice
Gilbert J. Grant,Yechezkel Barenholz,Boris Piskoun,Mylarrao Bansinath,Herman Turndorf,Elijah M. Bolotin +5 more
TL;DR: Compared to plain BUP, these Bupivacaine-DRV produced significant prolongation of analgesia, which is explained by longer residence time of the drug at the site of injection.
Journal ArticleDOI
Clinical Management of Pain in Rodents.
TL;DR: While gaps still exist in the understanding of clinical pain management in rodents, effective pharmacologic and nonpharmacologic strategies are available that can and should be used to provide analgesia while minimizing adverse effects.
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Local anesthetic effects of bupivacaine loaded lipid-polymer hybrid nanoparticles: In vitro and in vivo evaluation.
TL;DR: These results demonstrate that the BVC LPNs could function as promising drug delivery system for overcoming the drawbacks of poor stability and rapid drug leakage, and prolonging the anesthetic effect with slight toxicity.
References
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Journal ArticleDOI
Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix.
D. B. Masters,Charles B. Berde,Sanjoy Dutta,Chauncey T. Griggs,Delphine Hu,William Kupsky,Robert Langer +6 more
TL;DR: This biodegradable polymer system provides a promising new alternative for the delivery of local anesthetics to peripheral nerves to produce prolonged blockade for the management of acute and chronic pain.
Book
Opium Poppy: Botany, Chemistry, and Pharmacology
TL;DR: ContentsForeword * Preface * Introduction * Botanical Studies * Cytology and Genetic Studies * Agronomical Studies * Physiological Studies * Anatomical studies * Constitution of Amphicribal Vascular Bundles in Capsule
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Audible and ultrasonic vocalization elicited by single electrical nociceptive stimuli to the tail in the rat
TL;DR: It is concluded that a short stimulus applied to the tail triggers a complex behavioural repertoire and is proposed that this model will be a useful tool for physiological and pharmacological studies Of nociception.
Journal ArticleDOI
Prolonged analgesia with liposomal bupivacaine in a mouse model
TL;DR: This study shows that liposomal encapsulation of bupivacaine significantly prolongs duration of action and greatly decreases systemic toxicity of the drug.