Journal ArticleDOI
An updated view on the role of dopamine in myopia
TLDR
The observation that changes in dopamine levels can be locally induced by local retinal deprivation is in line with the assumption that dopaminergic mechanisms control both central and peripheral eye growth, and the dose-response function linking light exposure to dopamine and to the suppression of myopia is not known.About:
This article is published in Experimental Eye Research.The article was published on 2013-09-01. It has received 302 citations till now. The article focuses on the topics: Dopaminergic & Dopaminergic pathways.read more
Citations
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Dopamine receptors – IUPHAR Review 13
TL;DR: An update of the current knowledge regarding the complex biology, signalling, physiology and pharmacology of dopamine receptors is provided.
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Time outdoors and the prevention of myopia
TL;DR: Clinical trials are now underway to reduce the development of myopia in children by increasing the amount of time they spend outdoors, with more precise definition of thresholds for protection in terms of intensity and duration of light exposures.
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IMI - Report on Experimental Models of Emmetropization and Myopia.
David Troilo,Earl L. Smith,Debora L. Nickla,Regan Ashby,Andrei V. Tkatchenko,Lisa A Ostrin,Timothy J. Gawne,Machelle T. Pardue,Jody A. Summers,Chea-Su Kee,Falk Schroedl,Siegfried Wahl,Lyndon Jones +12 more
TL;DR: Experimental animal models continue to provide new insights into the cellular and molecular mechanisms of eye growth control, including the identification of potential new targets for drug development and future treatments needed to stem the increasing prevalence of myopia and the vision-threatening conditions associated with this disease.
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Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
Cream,UK Biobank Eye +1 more
TL;DR: The notion that refractive errors are caused by a light-dependent retina-to-sclera signaling cascade is supported and potential pathobiological molecular drivers are delineated.
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Dopamine signaling and myopia development: What are the key challenges
TL;DR: This review will revisit several key points of evidence for and against DA mediating light control of myopia, and identifies the key questions and challenges in translating basic knowledge on DA signaling and myopia from animal studies into effective pharmacological treatments for myopia in children.
References
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Outdoor Activity Reduces the Prevalence of Myopia in Children
Kathryn A. Rose,Ian G. Morgan,Jenny M. Ip,Annette Kifley,Son C. Huynh,Wayne Smith,Paul Mitchell +6 more
TL;DR: In the Sydney Myopia Study as discussed by the authors, the authors assessed the relationship of near, mid-working distance, and outdoor activities with prevalence of myopia in school-aged children and found that higher levels of outdoor activity (sport and leisure activities) were associated with more hyperopic refractions and lower myopia prevalence in the 12-year-old students.
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Homeostasis of Eye Growth and the Question of Myopia
Josh Wallman,Jonathan Winawer +1 more
TL;DR: If the match between the length and optics of the eye is under homeostatic control, why do children so commonly develop myopia, and why does the myopia not limit itself?
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Dopamine and retinal function
TL;DR: The experimental evidence in support of dopamine's role as a chemical messenger for light adaptation and its multiple trophic roles in retinal function related to circadian rhythmicity, cell survival and eye growth are summarized.
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Accommodation, refractive error and eye growth in chickens
TL;DR: It was found that the posterior nodal distance was increased in eyes which were treated with negative lenses compared to those treated with positive lenses, and this effect occurs independently in both eyes and it is not due to changes in corneal curvature.
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Parental History of Myopia, Sports and Outdoor Activities, and Future Myopia
Lisa A. Jones,Loraine T. Sinnott,Donald O. Mutti,Gladys L. Mitchell,Melvin L. Moeschberger,Karla Zadnik +5 more
TL;DR: In this article, the authors identify whether parental history of myopia and/or parent-reported children's visual activity levels can predict juvenile-onset myopia, and perform univariate and multiple logistic regression analyses and receiver operator characteristic (ROC) curves were generated.