Journal ArticleDOI
The wound healing process: an overview of the cellular and molecular mechanisms.
TLDR
Wound classification, the physiology of the wound healing process and the methods used in wound management are discussed.Abstract:
Wound healing remains a challenging clinical problem and correct, efficient wound management is essential. Much effort has been focused on wound care with an emphasis on new therapeutic approaches and the development of technologies for acute and chronic wound management. Wound healing involves multiple cell populations, the extracellular matrix and the action of soluble mediators such as growth factors and cytokines. Although the process of healing is continuous, it may be arbitrarily divided into four phases: (i) coagulation and haemostasis; (ii) inflammation; (iii) proliferation; and (iv) wound remodelling with scar tissue formation. The correct approach to wound management may effectively influence the clinical outcome. This review discusses wound classification, the physiology of the wound healing process and the methods used in wound management.read more
Citations
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Journal ArticleDOI
The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
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Hypoxia and the extracellular matrix: drivers of tumour metastasis
TL;DR: A direct link between hypoxia and the composition and the organization of the ECM is established, which suggests a new model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.
Journal ArticleDOI
Concise Review: Role of Mesenchymal Stem Cells in Wound Repair
TL;DR: Characterization of MSCs containing skin substitutes is described, demonstrating the presence of key growth factors and cytokines uniquely suited to aid in wound repair.
Journal ArticleDOI
Advanced Therapeutic Dressings for Effective Wound Healing—A Review
TL;DR: In this article, the current state of wound healing and wound management products, with emphasis on the demand for more advanced forms of wound therapy and some of the current challenges and driving forces behind this demand, are reviewed.
Journal ArticleDOI
Recent advances on antimicrobial wound dressing: A review.
Déborah Simões,Sónia P. Miguel,Maximiano P. Ribeiro,Paula Coutinho,António Mendonça,Ilídio J. Correia,Ilídio J. Correia +6 more
TL;DR: An overview of the most prominent antibacterial agents incorporated in wound Dressings along with their mode of action is provided and the recent advances in the therapeutic approaches used in the clinic and some future perspectives regarding antibacterial wound dressings are discussed.
References
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Journal ArticleDOI
Wound healing: an overview of acute, fibrotic and delayed healing.
TL;DR: This review describes the major biological processes associated with both normal and pathologic healing of acute wounds, characterized by four distinct, but overlapping phases: hemostasis, inflammation, proliferation and remodeling.
Journal ArticleDOI
The basic science of wound healing.
TL;DR: This article will attempt to provide a concise report of the current literature on wound healing by first reviewing the phases of wound healing followed by “the players” of wounds healing: inflammatory mediators (cytokines, growth factors, proteases, eicosanoids, kinins, and more), nitric oxide, and the cellular elements.
Journal ArticleDOI
Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.
Satoshi Takeshita,Lu P. Zheng,Edi Brogi,Marianne Kearney,Lee Li-Qun Pu,Stuart Bunting,Napoleone Ferrara,James F. Symes,Jeffrey M. Isner,Jeffrey M. Isner +9 more
TL;DR: Findings establish proof of principle for the concept that the angiogenic activity of VEGF is sufficiently potent to achieve therapeutic benefit and might ultimately be applicable to patients with severe limb ischemia secondary to arterial occlusive disease.
Journal ArticleDOI
General principles of wound healing
Maria B. Witte,Adrian Barbul +1 more
TL;DR: Better understanding of the complex wound-healing cascade helps the approach to wound healing and its possible failure and Manipulations of the involved immunologic features offer future therapeutic strategies.
Journal ArticleDOI
Definitions and Guidelines for Assessment of Wounds and Evaluation of Healing
Gerald S. Lazarus,Diane M. Cooper,David R. Knighton,David J. Margolis,Roger E. Pecoraro,George T. Rodeheaver,Martin C. Robson +6 more
TL;DR: The report that follows defines wound, acute wound, chronic wound, healing and forms of healing, wound assessment, wound extent, wound burden, and wound severity, broadly applicable to all wounds.