Journal ArticleDOI
Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation
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TLDR
It is shown that IgG acquires anti-inflammatory properties upon Fc sialylation, which is reduced upon the induction of an antigen-specific immune response, and may provide a switch from innate anti- inflammatory activity in the steady state to generating adaptive pro-inflammatory effects upon antigenic challenge.Abstract:
Immunoglobulin G (IgG) mediates pro- and anti-inflammatory activities through the engagement of its Fc fragment (Fc) with distinct Fcg receptors (FcgRs) One class of Fc-FcgR interactions generates pro-inflammatory effects of immune complexes and cytotoxic antibodies In contrast, therapeutic intravenous gamma globulin and its Fc fragments are anti-inflammatory We show here that these distinct properties of the IgG Fc result from differential sialylation of the Fc core polysaccharide IgG acquires anti-inflammatory properties upon Fc sialylation, which is reduced upon the induction of an antigen-specific immune response This differential sialylation may provide a switch from innate anti-inflammatory activity in the steady state to generating adaptive pro-inflammatory effects upon antigenic challengeread more
Citations
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Journal ArticleDOI
The trinity of COVID-19: immunity, inflammation and intervention.
Matthew Zirui Tay,Chek Meng Poh,Laurent Rénia,Laurent Rénia,Paul A. MacAry,Lisa F. P. Ng,Lisa F. P. Ng,Lisa F. P. Ng +7 more
TL;DR: The interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunctional immune responses to disease progression is described and the implications of these approaches for potential therapeutic interventions that target viral infection and/or immunoregulation are highlighted.
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Fcγ receptors as regulators of immune responses
TL;DR: Recent studies addressing the multifaceted roles of FcRs for IgG (FcγRs) in the immune system are discussed and how this knowledge could be translated into novel therapeutic strategies to treat human autoimmune, infectious or malignant diseases are discussed.
Journal ArticleDOI
Glycosylation in Cellular Mechanisms of Health and Disease
Kazuaki Ohtsubo,Jamey D. Marth +1 more
TL;DR: This review discusses the increasingly sophisticated molecular mechanisms being discovered by which mammalian glycosylation governs physiology and contributes to disease.
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IgG subclasses and allotypes: from structure to effector functions.
TL;DR: IgG-polymorphisms and post-translational modification of the antibodies in the form of glycosylation, affect IgG-function will be the focus of the current review.
Journal ArticleDOI
Structure and function of immunoglobulins.
TL;DR: Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains that can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
References
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Journal ArticleDOI
Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity
Robert L. Shields,Jadine Lai,Rodney G. Keck,Lori Y. O'Connell,Kyu Hong,Y. Gloria Meng,Stefanie Weikert,Leonard G. Presta +7 more
TL;DR: Antibody-dependent cellular cytot toxicity assays using purified peripheral blood monocytes or natural killer cells from several donors showed enhanced cytotoxicity, especially evident at lower antibody concentrations.
Journal ArticleDOI
High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood
Paul Imbach,V. d'APUZZO,Andreas Hirt,E. Rossi,M. Vest,Silvio Barandun,C. Baumgartner,Andreas Morell,Martin H. Schöni,H. P. Wagner +9 more
TL;DR: Seven children with chronic or intermittent ITP and six with acute idiopathic thrombocytopenic purpura were treated with large intravenous doses of polyvalent, intact immunoglobulin (Ig), and the platelet count rose sharply within 5 days, but the initial response and the subsequent course varied from patient to patient.
Journal ArticleDOI
Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG.
Raj B. Parekh,Raymond A. Dwek,B J Sutton,Daryl L. Fernandes,A. Leung,D. R. Stanworth,Thomas W. Rademacher,T. Mizuochi,Tadatsugu Taniguchi,K. Matsuta,Fujio Takeuchi,Yasutaka Nagano,T Miyamoto,Akira Kobata +13 more
TL;DR: The results indicate that IgG isolated from normal individuals, patients with RA and patients with OA contains different distributions of asparagine-linked bi-antennary complex-type oligosaccharide structures, and these two arthritides may therefore be glycosylation diseases, reflecting changes in the intracellular processing, or post-secretory degradation of N-linked oligOSaccharides.
Journal ArticleDOI
Fcγ Receptors: Old Friends and New Family Members
TL;DR: This review will summarize recent results in Fc-receptor biology with an emphasis on data obtained in in vivo model systems.
Journal ArticleDOI
Anti-inflammatory Activity of IVIG Mediated Through the Inhibitory Fc Receptor
TL;DR: Protection was associated with the ability of IVIG administration to induce surface expression of FcgammaRIIB on splenic macrophages, and modulation of inhibitory signaling is a potent therapeutic strategy for attenuating autoantibody-triggered inflammatory diseases.