Anti-microbial and Anti-inflammatory Activity of New 4-methoxy-3-(methoxymethyl) Phenol and (E)-N′-(5-bromo-2-methoxybenzylidene)-4-methoxy Benzohydrazide Isolated from Calotropis gigantean white
R. Manivannan,R. Shopna +1 more
TLDR
In this article, a new phenol and hydrazide derivatives were obtained for the first time from the C. giganteawhite by silica gel column chromatography.Abstract:
− A new phenol and hydrazide derivatives were obtained for the first time from the C. giganteawhite by silica gel column chromatography. The structure of the isolated compounds was identified by UV, IR NMR and MS. C. gigantea was scientifically reported for several medicinal properties viz. analgesic, antimicrobial and cytotoxic. In this screening work, anti-microbial activity of test compounds was found to be active against all organisms. Additionally, anti-inflammatory activity of the test groups has reduced the thickness of edema of the hind paw compared to the control group. Keywords−Calotropis gigantea white, anti-microbial activity, Anti-inflammatory activity, 4-methoxy-3-(methoxymethyl) phenol, (E)-N'-(5-bromo-2-methoxybenzylidene)-4-methoxy benzohydrazideread more
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Design, synthesis, structure activity relationship and molecular docking studies of thiophene-2-carboxamide Schiff base derivatives of benzohydrazide as novel acetylcholinesterase and butyrylcholinesterase inhibitors
Naghmana Kausar,Shahzad Murtaza,Muhammad Nadeem Arshad,Rubina Munir,Rahman Shah Zaib Saleem,Hummera Rafique,Abdul Tawab +6 more
TL;DR: Structural-activity relationship showed that para substitution of benzene ring with more electronegative groups enhanced the activities of compounds against the enzymes and binding interactions of the ligands with the active site of the enzymes were explored.
Journal ArticleDOI
Synthesis, characterization, biological evaluation and molecular docking studies of N-functionalized derivatives of 2-aminobenzohydrazide
Naghmana Kausar,Shahzad Murtaza,Muhammad Nadeem Arshad,Robina Rashid,Abdullah M. Asiri,Noman Javid,Mulazim Hussain Asim,Zaman Ashraf +7 more
TL;DR: In this paper, N-functionalized derivatives of methyl anthranilate were prepared by reacting it with various acid chlorides to give amide derivatives (1-3) which were further converted to benzohydrazide derivatives by reacting them with hydrazine.
Journal ArticleDOI
Genus Calotropis: A Hub of Medicinally Active Phytoconstituents
TL;DR: The present review provides comprehensive information about various phytochemical constituents of the plant along with their medicinal importance.
Journal ArticleDOI
Design, synthesis, crystal structure, <i>in vitro</i> cytotoxicity evaluation, density functional theory calculations and docking studies of 2-(benzamido) benzohydrazide derivatives as potent AChE and BChE inhibitors
Naghmana Kausar,Ki-Hyun Kim +1 more
TL;DR: A series of hydrazone derivatives of 2-(benzamido) benzohydrazide was designed, synthesized, and characterized utilizing FTIR, NMR and UV spectroscopic techniques along with mass spectrometry as discussed by the authors .
Journal ArticleDOI
In Vitro Clot Dissolving Activity of Carbomer Based Gel Containing Ethanolic Extract of Calotropis Gigantea Leaves
TL;DR: The activity of these experimental gels describes the possibility of development of new safe, and non reactive topical anti-clot gel products using herbal or plant components like C. gigantea extracts.
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Book
Basic and Clinical Pharmacology
TL;DR: Basic and clinical pharmacology , Basic and clinical Pharmacology , کتابخانه دیجیتال جندی شاپور اهواز
Journal ArticleDOI
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