Journal ArticleDOI
Antibacterial actions of secreted phospholipases A2. Review
TLDR
Secreted PLA2s may be potentially useful new endogenous antibiotics to combat infections including those caused by antibiotic-resistant bacteria such as methicillin-resistant staphylococci and vancomysin-resistant enterococci.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2008-01-01. It has received 188 citations till now. The article focuses on the topics: Gram-negative bacteria & Gram-positive bacteria.read more
Citations
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Journal ArticleDOI
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
TL;DR: An overview of the intestinal microbiota is provided and the cell biology of Paneth cells is described, emphasizing the composition of their secretions and the roles of these cells in intestinal host defence and homeostasis.
Journal ArticleDOI
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.
TL;DR: The phospholipase A2 (PLA2) superfamily traces its roots to the identification of lytic actions of snake venom at the end of the 19th century and to the late 1980’s when PLA2-like activities were reported in mammalian cells in contrast to extracellular secreted activities from venom and pancreas.
Journal ArticleDOI
Recent progress in phospholipase A₂ research: from cells to animals to humans.
Makoto Murakami,Yoshitaka Taketomi,Yoshimi Miki,Hiroyasu Sato,Tetsuya Hirabayashi,Kei Yamamoto +5 more
TL;DR: This review focuses on current understanding of the emerging biological functions of PLA₂s and related enzymes, which evolved along with eicosanoid receptors when vertebrates first appeared.
Journal ArticleDOI
Depletion of murine intestinal microbiota: Effects on gut mucosa and epithelial gene expression
Dag Henrik Reikvam,Alexander Erofeev,Anders Sandvik,Vedrana Grcic,Frode L. Jahnsen,Frode L. Jahnsen,Peter Gaustad,Kathy D. McCoy,Andrew J. Macpherson,Leonardo A. Meza-Zepeda,Leonardo A. Meza-Zepeda,Finn-Eirik Johansen,Finn-Eirik Johansen +12 more
TL;DR: A robust protocol for depleting conventionally raised mice of their cultivatable intestinal microbiota with antibiotics by gavage is presented and it is shown that the biological effect of this depletion phenocopies physiological characteristics of germ-free mice.
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Tear analysis in ocular surface diseases
Lei Zhou,Roger W. Beuerman +1 more
TL;DR: This review has discussed some key issues in the analysis of tears in the context of understanding and diagnosing eye disease using current technologies of proteomics and metabolomics, and for their potential for clinical application.
References
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Journal ArticleDOI
Peptide antibiotics and their role in innate immunity.
TL;DR: The results obtained imply that the polypeptide-like structure dominates in the structure derived from Polypeptides with S-S Bonds while in the case of Peptides Giving Mainly or Only fJ-Sheet Structures, the polymethine-rich structure is preferred.
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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.
David A. Six,Edward A. Dennis +1 more
TL;DR: This review updates the classification of the various PLA(2)'s now described in the literature, and expands or realignment of Groups VI, VII and VIII, as well as the addition of Group XIPLA(2) from plants.
Journal ArticleDOI
The phospholipase A2 superfamily and its group numbering system
TL;DR: The PLA(2) superfamily has grown continuously and over the intervening years has required several updates of this Group numbering system, so a number of new PLA( 2)s have been discovered and are now included in this update.
Journal ArticleDOI
Toll-like receptor–mediated NF-κB activation: a phylogenetically conserved paradigm in innate immunity
Guolong Zhang,Sankar Ghosh +1 more
TL;DR: The role of the conserved TLR/NF-κB signaling pathway in innate immunity, as well as its impact on adaptive immune responses, is focused on.
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Biochemistry and physiology of mammalian secreted phospholipases A2.
Gérard Lambeau,Michael H. Gelb +1 more