Journal ArticleDOI
Antibacterial Compounds from Mushrooms I: A Lanostane-Type Triterpene and Prenylphenol Derivatives from Jahnoporus hirtus and Albatrellus flettii and Their Activities Against Bacillus cereus and Enterococcus faecalis
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TLDR
One novel compound and three others were shown to possess antimicrobial activities against these gram-positive bacteria employed as surrogates for more virulent and dangerous pathogens.Abstract:
Antibacterial bioassay-guided fractionation of two American mushroom species, Jahnoporus hirtus and Albatrellus flettii, led to the isolation and identification of their major antibacterial constituents: 3,11-dioxolanosta-8,24( Z)-diene-26-oic acid (1) from J. hirtus and confluentin (2), grifolin (3), and neogrifolin (4) from A. flettii. Compound 1 is a new lanostane-type triterpene. All purified compounds were evaluated for their ability to inhibit the growth of Bacillus cereus and Enterococcus faecalis using standard MIC assays. Compounds 1- 4 demonstrated MIC values of 40, 20, 10, and 20 microg/mL, respectively, against B. cereus and MIC values of 32, 1.0, 0.5, and 0.5 microg/mL, respectively, against E. faecalis. Thus, one novel compound and three others were shown to possess antimicrobial activities against these gram-positive bacteria employed as surrogates for more virulent and dangerous pathogens.read more
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A Review on Antimicrobial Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds
Maria José Alves,Isabel C.F.R. Ferreira,Joana F. Dias,Vânia Teixeira,Anabela Martins,Manuela Pintado +5 more
TL;DR: Plectasin peptide, obtained from Pseudoplectania nigrella, is the isolated compound with the highest antimicrobial activity against gram-positive bacteria, while 2-aminoquinoline, isolated from Leucopaxillus albissimus, presents the highest antibacterial activity against Gram-negative bacteria.
Journal ArticleDOI
Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry
Dilani D. De Silva,Sylvie Rapior,Enge Sudarman,Marc Stadler,Jianchu Xu,S. Aisyah Alias,Kevin D. Hyde,Kevin D. Hyde +7 more
TL;DR: This review compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug discovery.
Journal ArticleDOI
Resource diversity of Chinese macrofungi: edible, medicinal and poisonous species.
TL;DR: The most common medicinal functions possessed by Chinese macrofungi are antitumor or anticancer, followed by antioxidant and antimicrobial, and these species could be treated as “Gold Mushrooms”.
Journal ArticleDOI
DNMT1 mediates metabolic reprogramming induced by Epstein–Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma
Xiangjian Luo,Liping Hong,Liping Hong,Can Cheng,Can Cheng,Namei Li,Namei Li,Xu Zhao,Xu Zhao,Feng Shi,Feng Shi,Ji-Kai Liu,Jia Fan,Jian Zhou,Ann M. Bode,Ya Cao +15 more
TL;DR: This work establishes a mechanistic connection between epigenetics and metabolism in EBV-positive NPC and provides further evidence for pathological classification based on CpG island methylator phenotype (CIMP) inEBV-associated malignancies.
References
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Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis—One Species on the Basis of Genetic Evidence
Erlendur Helgason,Ole Andreas Økstad,Dominique A. Caugant,Henning Johansen,Agnès Fouet,Michèle Mock,Ida K. Hegna,Anne-Brit Kolstø +7 more
TL;DR: It is shown by multilocus enzyme electrophoresis and by sequence analysis of nine chromosomal genes that B. anthracis should be considered a lineage of B. cereus and this determination is not only a formal matter of taxonomy but may also have consequences with respect to virulence and the potential of horizontal gene transfer within the B. Cereus group.
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Multiple-drug resistant enterococci: the nature of the problem and an agenda for the future.
TL;DR: Effective control of multiple-drug resistantEnterococci will require better understanding of the interaction between enterococci, the hospital environment, and humans, 2) prudent antibiotic use, 3) better contact isolation in hospitals and other patient care environments, and 4) improved surveillance.
Journal ArticleDOI
Antimicrobial steroids from the fungus Fomitopsis pinicola
TL;DR: Phytochemical examination of the dichloromethane extract of the European fungus Fomitopsis pinicola led to the isolation of a new lanostanoid derivative identified from spectral and chemical evidences as 3 alpha-acetyloxylanosta++ +-8,24-dien-21-oic acid.
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Euphane and tirucallane triterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus.
TL;DR: Four new euphane-type triterpenes were isolated from a 60% EtOH extract of Euphorbia kansui, together with alpha-euphol, and their structures were elucidated on the basis of extensive analysis of their 1D and 2D NMR spectral data.
Journal ArticleDOI
Neogrifolin derivatives possessing anti-oxidative activity from the mushroom Albatrellus ovinus.
Makiko Nukata,Toshihiro Hashimoto,Isao Yamamoto,Nobuki Iwasaki,Masami Tanaka,Yoshinori Asakawa +5 more
TL;DR: 3-Hydroxyneogrifolin and 1-formyl-3-hydroxy-neogRifolin showed more potent antioxidative activity properties than either alpha-tocopherol or BHA.