Journal ArticleDOI
Antibiotic Resistance and the MRSA Problem
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TLDR
Besides development of new small molecules affecting cell viability, alternative approaches including anti-virulence and bacteriophage therapeutics are being investigated and may become important tools to combat staphylococcal infections in the future.Abstract:
Staphylococcus aureus is capable of becoming resistant to all classes of antibiotics clinically available and resistance can develop through de novo mutations in chromosomal genes or through acquisition of horizontally transferred resistance determinants. This review covers the most important antibiotics available for treatment of S. aureus infections and a special emphasis is dedicated to the current knowledge of the wide variety of resistance mechanisms that S. aureus employ to withstand antibiotics. Since resistance development has been inevitable for all currently available antibiotics, new therapies are continuously under development. Besides development of new small molecules affecting cell viability, alternative approaches including anti-virulence and bacteriophage therapeutics are being investigated and may become important tools to combat staphylococcal infections in the future.read more
Citations
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Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus.
TL;DR: The research status of MSSA and MRSA, the detailed mechanisms of the intrinsic antibiotic resistance and the acquired antibiotic resistance, the advanced research on anti-MRSA antibiotics and novel therapeutic strategies for MRSA treatment are reviewed.
Journal ArticleDOI
Bacterial Antibiotic Resistance: The Most Critical Pathogens.
TL;DR: In this paper, both the mode of action and the mechanisms of resistance of commonly used antimicrobials are examined and the current state of AMR in the most critical resistant bacteria as determined by the WHO's global priority pathogens list.
Dissemination of an Enterococcus Inc18-Like vanA Plasmid, Associated with Vancomycin-Resistant Staphylococcus aureus
TL;DR: In this article, a vancomycin-resistant Staphylococcus aureus (VRSA) case reported to date in the literature, 7 occurred in Michigan.
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Potentials of nanotechnology in treatment of methicillin-resistant Staphylococcus aureus.
TL;DR: A comprehensive understanding of the drug resistance mechanisms of MRSA is provided and the potential applications of some functionalized nanomaterials in anti-MRSA therapy are discussed.
Journal ArticleDOI
Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus
Harshad Lade,Jae Seok Kim +1 more
TL;DR: In this article, the authors review the mechanism of action of antibiotics from different classes and discuss insights into the well-established primary targets in Staphylococcus aureus, including cell wall synthesis, protein synthesis (translation), DNA replication, RNA synthesis (transcription), and metabolic processes, such as folic acid synthesis.
References
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Journal ArticleDOI
Staphylococcus aureus infections.
TL;DR: In an elegant series of clinical observations and laboratory studies published in 1880 and 1882, Ogston described staphylococcal disease and its role in sepsis and abscess formation.
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Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
Ian Chopra,Marilyn C. Roberts +1 more
TL;DR: Changing the use of tetracyclines in human and animal health as well as in food production is needed if this class of broad-spectrum antimicrobials through the present century is to continue to be used.
Journal ArticleDOI
Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children
Catherine Liu,Arnold S. Bayer,Sara E. Cosgrove,Robert S. Daum,Scott K. Fridkin,Rachel J. Gorwitz,Sheldon L. Kaplan,Adolf W. Karchmer,Donald P. Levine,Barbara E. Murray,Michael J. Rybak,Henry F. Chambers +11 more
TL;DR: These guidelines discuss the management of a variety of clinical syndromes associated with MRSA disease, including skin and soft tissue infections (SSTI), bacteremia and endocarditis, pneumonia, bone and joint infections, and central nervous system infections.
Journal ArticleDOI
Waves of resistance: Staphylococcus aureus in the antibiotic era
Henry F. Chambers,Frank R. DeLeo +1 more
TL;DR: The molecular epidemiology of the epidemic waves of peniillin- and methicillin-resistant strains of S. aureus that have occurred since 1940 are reviewed, with a focus on the clinical and molecular epidemiological of CA-MRSA.