Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.
Nicholas A Turner,Batu K. Sharma-Kuinkel,Stacey A. Maskarinec,Emily M. Eichenberger,Pratik Shah,Manuela Carugati,Manuela Carugati,Thomas L. Holland,Vance G. Fowler,Vance G. Fowler +9 more
TLDR
An overview of basic and clinical MRSA research is provided and the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA is explored.Abstract:
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.read more
Citations
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Antimicrobial resistance in ESKAPE pathogens
David M. P. De Oliveira,Brian M. Forde,Timothy J. Kidd,Patrick N A Harris,Mark A. Schembri,Scott A. Beatson,David L. Paterson,Mark J. Walker +7 more
TL;DR: The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antim antibiotic resistance surveillance.
Journal ArticleDOI
Pathogenicity and virulence of Staphylococcus aureus.
TL;DR: Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent This pathogen can cause a wide variety of diseases, ranging from moderately
Journal ArticleDOI
Vancomycin resistant Staphylococcus aureus infections: A review of case updating and clinical features
TL;DR: In this article, the authors review the latest progresses in VRSA, highlighting its resistance mechanism, characteristics of VRSA infections, as well as clinical treatments, and highlight its resistance mechanisms.
Journal ArticleDOI
The Continuing Threat of Methicillin-Resistant Staphylococcus aureus.
TL;DR: The aim of this review is to recap the history, the emergence, and clinical features of various MRSA infections, and to summarize the current advances regarding MRSA screening, typing, and therapeutic options for an audience of clinical microbiologists and infectious disease specialists.
Journal ArticleDOI
β-lactam antibiotics: An overview from a medicinal chemistry perspective.
TL;DR: The different classes of beta-lactam antibiotics (penicillins, cephalosporins, carbapenems, monobactams and penems) are discussed in light of their stability, sensitivity to β- lactamases, mechanism of action and spectrum of antimicrobial activity.
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