Journal ArticleDOI
Antibiotic resistance of bacteria in biofilms
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TLDR
The features of biofilm infections are summarized, the emerging mechanisms of resistance are reviewed, and potential therapies are discussed.About:
This article is published in The Lancet.The article was published on 2001-07-14. It has received 4116 citations till now. The article focuses on the topics: Biofilm & Antibacterial agent.read more
Citations
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Bacterial biofilms: from the natural environment to infectious diseases.
TL;DR: It is evident that biofilm formation is an ancient and integral component of the prokaryotic life cycle, and is a key factor for survival in diverse environments.
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Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management
TL;DR: This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of S. aureus as a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections.
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Graphene-Based Antibacterial Paper
TL;DR: Graphene-based nanomaterials can effectively inhibit the growth of E. coli bacteria while showing minimal cytotoxicity and it is demonstrated that macroscopic freestanding GO and rGO paper can be conveniently fabricated from their suspension via simple vacuum filtration.
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Biofilms: the matrix revisited
TL;DR: This review discusses recent advances in the understanding of the extracellular matrix and its role in biofilm biology and describes how this contributes significantly to the organization of the community.
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Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
TL;DR: This review systematically introduces the classification, catalytic mechanism, activity regulation as well as recent research progress of nanozymes in the field of biosensing, environmental protection, and disease treatments, etc. in the past years.
References
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Journal ArticleDOI
Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
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Mechanisms of biofilm resistance to antimicrobial agents
Thien-Fah Mah,George A. O'Toole +1 more
TL;DR: Owing to the heterogeneous nature of the biofilm, it is likely that there are multiple resistance mechanisms at work within a single community.
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Biofilm Formation as Microbial Development
TL;DR: The results reviewed in this article indicate that the formation of biofilms serves as a new model system for the study of microbial development.
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The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms
TL;DR: Minimal biofilm eradication concentrations, derived by using the Calgary Biofilm Device, demonstrated that for biofilms of the same organisms, 100 to 1,000 times the concentration of a certain antibiotic were often required for the antibiotic to be effective, while other antibiotics were found to beeffective at the MICs.
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Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
Pradeep K. Singh,Amy L. Schaefer,Matthew R. Parsek,Thomas O. Moninger,Michael J. Welsh,E. P. Greenberg +5 more
TL;DR: The hypothesis that P. aeruginosa might exist as biofilms—structured communities of bacteria encased in a self-produced polymeric matrix—in the cystic fibrosis lung is supported by microscopy of cystic Fibrosis sputum, which shows that the bacterium are in biofilm-like structures.