Antibody Response and Variant Cross-Neutralization After SARS-CoV-2 Breakthrough Infection
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Association of Prior SARS-CoV-2 Infection with Risk of Breakthrough Infection Following mRNA Vaccination in Qatar as mentioned in this paper , which is the case of SARS CoV2 infection.Abstract:
Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar read more
Citations
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Evolution of the SARS‐CoV‐2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission
TL;DR: The theories that have been proposed on the evolution of Omicron including zoonotic spillage, infection in immunocompromised individuals and cryptic spread in the community without being diagnosed are examined.
Journal ArticleDOI
SARS-CoV-2 reinfections: Overview of efficacy and duration of natural and hybrid immunity
TL;DR: In this paper , a narrative review provides an overview on epidemiological studies addressing the issue of SARS-CoV-2 infection and the efficacy and duration of natural immunity in terms of protection against reinfections and severe disease.
Journal ArticleDOI
Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
John E. Bowen,Amin Addetia,Ha V. Dang,Cameron Stewart,Jack T Brown,William K Sharkey,Kaitlin R. Sprouse,Alexandra C. Walls,Ignacio Mazzitelli,Jennifer Logue,Nicholas Franko,Nadine Czudnochowski,Abigail E. Powell,Exequiel Dellota,Kumail Ahmed,A. S. Ansari,Elisabetta Cameroni,Andrea Gori,Alessandra Bandera,Christine M. Posavad,Jennifer M. Dan,Zeli Zhang,Daniela Weiskopf,Alessandro Sette,Shane Crotty,Najeeha Talat Iqbal,Davide Corti,Jorge Geffner,Gyorgy Snell,Renata Grifantini,Helen Y. Chu,David Veesler +31 more
TL;DR: It is suggested that although Omicron sublineages evade polyclonal neutralizing antibody responses elicited by primary vaccine series, vaccine boosters may provide sufficient protection against Omicrons-induced severe disease.
Journal ArticleDOI
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
Young-Jun Park,Dora Pinto,Alexandra C. Walls,Zhuoming Li,Anna De Marco,Fabio Benigni,Fabrizia Zatta,Chiara Silacci-Fregni,Jessica Bassi,Kaitlin R. Sprouse,Amin Addetia,John E. Bowen,Cameron Stewart,Martina Giurdanella,Christian Saliba,Barbara Guarino,Michael Schmid,Nicholas Franko,Jennifer Logue,Ha V. Dang,Kevin Hauser,J. Di Iulio,William A. Rivera,Gretja Schnell,Anushka Rajesh,Jiayi Zhou,Nisar A. Farhat,Hannah Kaiser,Martin Montiel-Ruiz,Julia Noack,Florian A. Lempp,Javier Janer,Rana Abdelnabi,Piet Maes,Paolo Ferrari,Alessandro Ceschi,Olivier Giannini,G. D. de Melo,Lauriane Kergoat,Hervé Bourhy,Johan Neyts,Leah Soriaga,Lisa A. Purcell,Gyorgy Snell,Sean P. J. Whelan,Antonio Lanzavecchia,Herbert W. Virgin,Luca Piccoli,Helen Y. Chu,Matteo Samuele Pizzuto,Davide Corti,David Veesler +51 more
TL;DR: It is shown that hybrid immunity or vaccine boosters result in potent plasma neutralizing activity against Omicron BA.1 and BA.2 and that breakthrough infections, but not vaccination-only, induceneutralizing activity in the nasal mucosa.
Journal ArticleDOI
Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infection
Chengzi I. Kaku,Alan Bergeron,Clas Ahlm,Johan Normark,Mrunal Sakharkar,Mattias N. E. Forsell,Laura M. Walker +6 more
TL;DR: Kaku et al. as discussed by the authors investigated the role of preexisting immunity in shaping the B cell response to heterologous SARS-CoV-2 variant exposure and found that introducing a mutant S to someone immune to ancestral S provides robust immune responses, providing implications for potential future vaccination strategies.
References
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Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant.
Jamie Lopez Bernal,Nick Andrews,Charlotte Gower,Eileen Gallagher,Ruth Simmons,Simon Thelwall,Julia Stowe,Elise Tessier,Natalie Groves,Gavin Dabrera,Richard H. Myers,Colin Campbell,Gayatri Amirthalingam,Matt Edmunds,Maria Zambon,Kevin E. Brown,Susan Hopkins,Meera Chand,Mary Ramsay +18 more
TL;DR: The B.617.1.2 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Coronavirus disease 2019 (Covid-19), has contributed to the development of the disease.
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Covid-19 Breakthrough Infections in Vaccinated Health Care Workers.
Moriah Bergwerk,Tal Gonen,Yaniv Lustig,Sharon Amit,Marc Lipsitch,Carmit Cohen,Michal Mandelboim,Einav G Levin,Carmit Rubin,Victoria Indenbaum,Ilana Tal,Malka Zavitan,Neta S. Zuckerman,Adina Bar-Chaim,Yitshak Kreiss,Gili Regev-Yochay +15 more
TL;DR: Despite the high efficacy of the BNT162b2 messenger RNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough infections have been reported.
Journal ArticleDOI
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.
Rita E. Chen,Xianwen Zhang,James Brett Case,Emma S. Winkler,Yang Liu,Laura A. VanBlargan,Jianying Liu,John M. Errico,Xuping Xie,Naveenchandra Suryadevara,Pavlo Gilchuk,Seth J. Zost,Stephen Tahan,Lindsay Droit,Jackson S. Turner,Wooseob Kim,Aaron J. Schmitz,Mahima Thapa,David Wang,Adrianus C. M. Boon,Rachel M. Presti,Jane A. O’Halloran,Alfred H.J. Kim,Parakkal Deepak,Dora Pinto,Daved H. Fremont,James E. Crowe,Davide Corti,Herbert W. Virgin,Herbert W. Virgin,Ali H. Ellebedy,Pei Yong Shi,Michael S. Diamond +32 more
TL;DR: In this article, using monoclonal antibodies (mAbs), animal immune sera, human convalescent sera and human sera from recipients of the BNT162b2 mRNA vaccine, the authors report the impact on antibody neutralization of a panel of authentic SARS-CoV-2 variants including a B.1.7 isolate, chimeric strains with South African or Brazilian spike genes and isogenic recombinant viral variants.
Journal ArticleDOI
SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3.
Ann R. Falsey,Robert W. Frenck,Edward E. Walsh,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,Ruth Bailey,Kena A. Swanson,Xia Xu,Kenneth Koury,Warren Kalina,David A. Cooper,Jing Zou,Xuping Xie,Hongjie Xia,Özlem Türeci,Eleni Lagkadinou,Tompkins Kristin Rachael,Pei Yong Shi,Kathrin U. Jansen,Ugur Sahin,Philip R. Dormitzer,William C. Gruber +23 more
TL;DR: In this paper, a third dose of the BNT162b2 vaccine was administered to 23 volunteers 8 to 9 months after the second dose, and the immune response was assessed.
Journal ArticleDOI
An observational study of breakthrough SARS-CoV-2 Delta variant infections among vaccinated healthcare workers in Vietnam.
Nguyen Van Vinh Chau,Nghiem My Ngoc,Lam Anh Nguyet,Vo Minh Quang,Nguyen Thi Han Ny,Dao Bach Khoa,Nguyen Thanh Phong,Le Mau Toan,Nguyen Thi Thu Hong,Nguyen Thi Kim Tuyen,Voong Vinh Phat,Le Nguyen Truc Nhu,Nguyen Huynh Thanh Truc,Bui Thi Ton That,Huynh Phuong Thao,Tran Nguyen Phuong Thao,Vo Trong Vuong,Tran Thi Thanh Tam,Ngo Tan Tai,Huynh Thi Kim Nhung,Nguyen Thi Ngoc Minh,Nguyen Thi My Tien,Nguy Cam Huy,Marc Choisy,Dinh Nguyen Huy Man,Dinh Thi Bich Ty,Nguyen To Anh,Le Thi Tam Uyen,Tran Hoang Tu,Lam Minh Yen,Nguyen Thanh Dung,Le Manh Hung,Nguyen Thanh Truong,Tran Tan Thanh,Guy E. Thwaites,Le Van Tan +35 more
TL;DR: In this paper, the authors studied breakthrough infections among Oxford-AstraZeneca vaccinated healthcare workers in an infectious diseases hospital in Vietnam, and collected demographic and clinical data alongside serial PCR testing, measurement of SARS-CoV-2 antibodies, and viral whole-genome sequencing.
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