Journal ArticleDOI
Antifungal mode of action of triforine
James L. Sherald,Hugh D. Sisler +1 more
TLDR
Investigation of 4,4-dimethyl-Δ 8, 24 (28) -ergostadienol in untreated mycelia indicates that the C-14 methyl group is the first methyl group removed in the biosynthesis of ergosterol by A. fumigatus, which implies that both fungicides inhibit sterol C- 14 demethylation.About:
This article is published in Pesticide Biochemistry and Physiology.The article was published on 1975-10-01. It has received 61 citations till now. The article focuses on the topics: Ergosterol & Sterol.read more
Citations
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Book ChapterDOI
Biochemical Targets for Antifungal Azole Derivatives: Hypothesis on the Mode of Action
TL;DR: An amazing number of antifungal agents are found within the group of azole-containing compounds, and they show excellent activity against phytopathogenic fungi.
Journal ArticleDOI
Biochemical effects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans
TL;DR: The effects of the antifungal agent miconazole nitrate on the ergosterol biosynthesis in Candida albicans were investigated after in vitro contact with the drug and the accumulation of 14 α-methyl sterols suggests that this antifundal agent is a potent inhibitor of one of the metabolic steps involved in the demethylation at C-14.
Journal ArticleDOI
Metabolism of sterols in yeast.
TL;DR: In this article, the Metabolism of Sterols in Yeast was investigated and the results showed that it is a function of the number of chromosomes in the Yeast population.
Genetics of fungal resistance to systemic fungicides
TL;DR: It was concluded that imazalil and pimaricin, for which the level of resistance in relation to the wild type increased at most by a factor 10 and 4, respectively, might be used in agriculture without a considerable chance of interference with control.
Journal ArticleDOI
Effects of sterol biosynthesis-inhibiting (SBI) fungicides on cytochrome P-450 oxygenations in fungi
Matthew J. Henry,Hugh D. Sisler +1 more
TL;DR: The data suggest that the primary action of sterol biosynthesis-inhibiting (SBI) fungicides is competitive inhibition of sterl/steroid-type cytochrome P -450 enzymes rather than interference with the function of sterols carrier proteins or enzyme-modulating phospholipids.
References
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Journal ArticleDOI
A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
Journal ArticleDOI
Metabolic control of enzymes involved in lipogenesis and gluconeogenesis.
Journal ArticleDOI
Interaction of Mixed-Function Oxidation with Biosynthetic Processes
TL;DR: It is assumed that the observed inhibition of gluconeogenesis is not specific for mixed-function oxidation, but may be an example for a more general mechanism of metabolic interdependences involving the extramitochondrial NADPH pool.
Journal ArticleDOI
Relation between structure and retention time of sterols in gas chromatograpphy
Journal ArticleDOI
Sterols of the fungi: Distribution and biosynthesis
TL;DR: The composition and biosynthesis of ergosterol in these organisms and comparison to plant and animal sterol formation are made are made.