Journal ArticleDOI
Antigenic hybrids of influenza a viruses with surface antigens to order
TLDR
Stable antigenic hybrids between mammalian and avian strains of influenza A viruses with the hemagglutinin from one parent and the neuraminidase antigen from the other parent can be made to order in the allantois-on-shell system.About:
This article is published in Virology.The article was published on 1970-11-01. It has received 91 citations till now. The article focuses on the topics: Antigenic drift & Antigenic shift.read more
Citations
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Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses
Yasuo Suzuki,Toshihiro Ito,Takashi Suzuki,Robert E. Holland,Thomas M. Chambers,Makoto Kiso,Hideharu Ishida,Yoshihiro Kawaoka,Yoshihiro Kawaoka +8 more
TL;DR: In this paper, the authors examined the requirement for the hemagglutinin (HA) for support of viral replication in horses, using viruses whose HAs differ in receptor specificity.
Journal ArticleDOI
The prevalence of influenza viruses in swine and the antigenic and genetic relatedness of influenza viruses from man and swine
TL;DR: Serological and virological surveillance of swine during 1976-77 showed that Hsw1N1 influenza viruses were prevalent throughout the swine population of the U.S., particularly in the northern states.
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Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en.
TL;DR: It is demonstrated that amino acid substitution in the NA active site at the catalytic or framework residues, followed by multiple passages in vitro, in the presence of increasing concentrations of the NA inhibitor GG167, generates GG167-resistant viruses with reduced NA activity and decreased infectivity in animals.
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Studies on the origin of pandemic influenza: III. Evidence implicating duck and equine influenza viruses as possible progenitors of the Hong Kong strain of human influenza
W.G. Laver,Robert G. Webster +1 more
TL;DR: Peptide maps showed that the light polypeptide chains from the hemagglutinin subunits of these animal, avian and human viruses had practically the same amino acid sequence, indicating that the three viruses arose, by genetic recombination, from a common ancestor.
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Antigenic and genetic characterization of a novel hemagglutinin subtype of influenza A viruses from gulls.
TL;DR: Comparison of the nucleotide sequences (and deduced amino acid sequences) of the 3' 20% of the HA genes of these viruses indicates that the gull viruses represent a genetically distinct group.
References
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Journal ArticleDOI
The thiobarbituric acid assay of sialic acids.
TL;DR: This chapter discusses the different aspects of thiobarbituric acid assay of sialic acid, which is suitable for measuring the release of bound sialoic acid by sialidase and hydrolysis of sIALic acid-containing material must be carried out for the measurement of total sialsic acids.
Journal ArticleDOI
Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.
Journal ArticleDOI
Disquisitions on original antigenic sin : i. evidence in man
TL;DR: The basic difference between primary and secondary reactivity rests on the presence of a trapping mechanism that allows anamnestic production of antibody against lower doses of the homologous antigen, thus preventing a standard primary response and allowing manifestations of Original Antigenic Sin.
Journal ArticleDOI
Antiviral Activity of Antiserum Specific for an Influenza Virus Neuraminidase
Edwin D. Kilbourne,Edwin D. Kilbourne,W. G. Laver,W. G. Laver,Jerome L. Schulman,Jerome L. Schulman,R. G. Webster,R. G. Webster +7 more
TL;DR: It is concluded that an antiserum specific for A(2) neuraminidase influenced the yield and release of virus from influenza virus-infected cells.
Related Papers (5)
Studies on the origin of pandemic influenza: III. Evidence implicating duck and equine influenza viruses as possible progenitors of the Hong Kong strain of human influenza
W.G. Laver,Robert G. Webster +1 more