Antimicrobial activities of silver dressings: an in vitro comparison.
TLDR
Understanding the characteristics of silver-coated or -impregnated dressings may enable them to be targeted more appropriately according to the specific requirements for use of a particular dressing, as in for prophylaxis in skin grafting or for an infected wound with MRSA.Abstract:
A range of silver-coated or -impregnated dressings are now commercially available for use but comparative data on their antimicrobial efficacies are limited. The antibacterial activities of five commercially available silver-coated/impregnated dressings were compared against nine common burn-wound pathogens, namely methicillin-sensitive and -resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Enterobacter cloacae, Proteus vulgaris, Acinetobacter baumannii and a multi-drug-efflux-positive Acinetobacter baumannii (BM4454), using a broth culture method. The rapidity and extent of killing of these pathogens under in vitro conditions were evaluated. All five silver-impregnated dressings investigated exerted bactericidal activity, particularly against Gram-negative bacteria, including Enterobacter species, Proteus species and E. coli. The spectrum and rapidity of action, however, ranged widely for different dressings. Acticoat and Contreet had a broad spectrum of bactericidal activities against both Gram-positive and -negative bacteria. Contreet was characterized by a very rapid bactericidal action and achieved a reduction of > or =10,000 c.f.u. ml(-1) in the first 30 min for Enterobacter cloacae, Proteus vulgaris, Pseudomonas aeruginosa and Acinetobacter baumanii. Other dressings demonstrated a narrower range of bactericidal activities. Understanding the characteristics of these dressings may enable them to be targeted more appropriately according to the specific requirements for use of a particular dressing, as in for prophylaxis in skin grafting or for an infected wound with MRSA.read more
Citations
More filters
Journal ArticleDOI
Aegiceras corniculatum -Mediated Green Synthesis of Silver Nanoparticles: Biophysical Characterization and Cytotoxicity on Vero Cells
Sekar Dinesh Kumar,Ganesan Singaravelu,Kadarkarai Murugan,Singaravelu Ajithkumar,Karthikeyan Sivashanmugam,Marcello Nicoletti,Giovanni Benelli +6 more
TL;DR: Results showed that the mangrove-fabricated silver nanoparticles was more biocompatible when compared with chemically synthesizedsilver nanoparticles, highlighting their promising potential as nanocarriers in pharmacology and nanomedicine.
Book ChapterDOI
UV–Vis. Spectroscopy: Herbal Drugs and Fingerprints
TL;DR: The prediction by UV–Vis spectrum for the skeleton of molecule and its functional group(s), present in extract form, help to develop method of isolation and purification.
Journal ArticleDOI
Estudio in vitro de las propiedades antimicrobianas de una espuma de poliuretano que libera iones de plata
José Miguel Sahuquillo Arce,Agustín Iranzo Tatay,Martín Llácer Luna,Yovana Sanchis Boix,Jorge Guitán Deltell,Eva González Barberá,Joycelyna Beltrán Heras,Miguel Gobernado Serrano +7 more
TL;DR: Las concentraciones de Ag + no fueron citotoxicas sobre fibroblastos humanos, sin observar diferencias entre las celulas expuestas a Ag + y los controles, se presenta como una buena alternativa para el control y prevencion local of las infecciones.
Journal Article
An in vitro comparison of two silver-containing antimicrobial wound dressings .
TL;DR: The results of this study confirm the broad-spectrum, in vitro activity of some dressings containing ionic silver, and the in vitro antimicrobial efficacy of both wound dressings was comparable, but clinical studies comparing the efficacy and effectiveness of silver-containing dressings to nonionic silver- containing dressings are needed.
References
More filters
Journal ArticleDOI
Bacterial silver resistance: molecular biology and uses and misuses of silver compounds
TL;DR: Resistance to silver compounds as determined by bacterial plasmids and genes has been defined by molecular genetics and the use of molecular epidemiological tools will establish the range and diversity of such resistance systems in clinical and non-clinical sources.
Journal ArticleDOI
Silver-based crystalline nanoparticles, microbially fabricated
TL;DR: Transmission electron microscopy, quantitative energy-dispersive x-ray analysis, and electron diffraction established that the crystals comprise at least three different types, found both in whole cells and thin sections, in Pseudomonas stutzeri AG259.
Journal ArticleDOI
Silver nanoparticles and polymeric medical devices: a new approach to prevention of infection?
Franck Furno,Kelly S. Morley,Ben Wong,Barry L. Sharp,Polly L. Arnold,Steven M. Howdle,Roger Bayston,Paul D. Brown,Peter D. Winship,Helen J. Reid +9 more
TL;DR: A completely new approach using supercritical carbon dioxide to impregnate silicone with nanoparticulate silver metal allows for the first time silver impregnation of medical polymers and promises to lead to an antimicrobial biomaterial whose activity is not restricted by increasing antibiotic resistance.
Journal ArticleDOI
Silver. I: Its antibacterial properties and mechanism of action.
TL;DR: The main mechanism of action of silver products, which are broad-spectrum antibiotics and are not yet associated with drug resistance, is described.
Related Papers (5)
Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria
Ivan Sondi,Branka Salopek-Sondi +1 more