Antimicrobial Activity of a New Class of Phosphorylated and Modified Flavonoids.
Francis J. Osonga,Ali Akgul,Roland M. Miller,Gaddi B Eshun,Idris Yazgan,Ayfer Akgul,Omowunmi A. Sadik +6 more
- Vol. 4, Iss: 7, pp 12865-12871
TLDR
Modified flavonoids could be used as a suitable alternative antimicrobial agent for the treatment of infectious diseases because of their antibacterial activity against pathogenic bacteria.Abstract:
The surge of resistant food pathogens is a major threat worldwide. Previous research conducted on phytochemicals has shown their antibacterial activity against pathogenic bacteria. The design of antimicrobial agents to curb pathogenic disease remains a challenge demanding critical attention. Flavonoids such as apigenin and quercetin were evaluated against Gram-positive and Gram-negative bacteria. The results indicated that the antibacterial activity of each flavonoid occurred at a different minimum inhibitory concentration. However, the antimicrobial activity results of the modified flavonoids were also reported, and it was observed that the Gram-positive bacteria were more susceptible in comparison to the Gram-negative bacteria. The cell wall structure of the Gram-positive and Gram-negative bacteria could be the main reason for the bacteria susceptibility. Modified flavonoids could be used as a suitable alternative antimicrobial agent for the treatment of infectious diseases. Our results indicated 100% inhibition of Listeria monocytogenes, Pseudomonas aeruginosa, and Aeromonas hydrophila with modified flavonoids.read more
Citations
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The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin.
Gaber El-Saber Batiha,Gaber El-Saber Batiha,Amany Magdy Beshbishy,Muhammad Ikram,Zohair S Mulla,Mohamed E. Abd El-Hack,Ayman E. Taha,Abdelazeem M. Algammal,Yaser Hosny Ali Elewa,Yaser Hosny Ali Elewa +9 more
TL;DR: Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis.
Journal ArticleDOI
Antimicrobial Activity of Quercetin: An Approach to Its Mechanistic Principle
TL;DR: The antimicrobial activity of quercetin is summarized with a special focus on its mechanistic principle, and the implications for its use as a clinically relevant antimicrobial agent are summarized.
Journal ArticleDOI
Antibiofilm effects of quercetin against Salmonella enterica biofilm formation and virulence, stress response, and quorum-sensing gene expression
Yu Kyung Kim,Pantu Kumar Roy,Md. Ashrafudoulla,Shamsun Nahar,Sazzad Hossen Toushik,Md. Iqbal Hossain,Md. Furkanur Rahaman Mizan,Si Hong Park,Sang-Do Ha +8 more
TL;DR: In this article , the inhibitory effect of quercetin (0.50-2.61 log CFU/cm2 (125, 1.2, 62.5, 1/4, and 31.25 μg/mL) on S. Typhimurium and S. Enteritidis on PLA, rubber gloves, and chicken skin during biofilm formation was investigated.
Journal ArticleDOI
Flavonoid-Coated Gold Nanoparticles as Efficient Antibiotics against Gram-Negative Bacteria—Evidence from In Silico-Supported In Vitro Studies
Hani A. Alhadrami,Raha Orfali,Ahmed A. Hamed,Mohammed M. Ghoneim,Hossam M. Hassan,Ahmed S. I. Hassane,Mostafa E. Rateb,Ahmed M. Sayed,Noha M. Gamaleldin +8 more
TL;DR: In this article, a number of flavonoid-coated gold nanoparticles (GNPs) were designed to enhance the antibacterial effects of chrysin, kaempferol, and quercetin against Gram-negative bacteria.
Journal ArticleDOI
Radical Scavenging and Antimicrobial Properties of Polyphenol Rich Waste Wood Extracts.
Anita Smailagić,Petar Ristivojević,Ivica Dimkić,Tamara Pavlović,Dragana Dabić Zagorac,Sonja Veljović,Milica Fotirić Akšić,Mekjell Meland,Maja Natić +8 more
TL;DR: This work provided simple, low-cost and high-throughput screening of phenolic compounds and assessments of the radical scavenging properties of selected individual metabolites from natural matrix that contributed to scavenge free radicals.
References
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Journal ArticleDOI
Antimicrobial activity of flavonoids
T.P. Tim Cushnie,Andrew J. Lamb +1 more
TL;DR: Several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents.
Journal ArticleDOI
The Bacterial Cell Envelope
TL;DR: The bacteria cell envelope is a complex multilayered structure that serves to protect these organisms from their unpredictable and often hostile environment.
Journal ArticleDOI
Flavonoids, a class of natural products of high pharmacological potency
TL;DR: The few existing reports on the careful pharmacodynamic, pharmacokinetic and clinical studies which have been made have been summarized to provide a basis for a full-scale investigation of the therapeutic potential of flavonoids.
Journal ArticleDOI
Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist.
TL;DR: Pseudomonas aeruginosa is an ubiquitous pathogen capable of infecting virtually all tissues as discussed by the authors, and a large variety of virulence factors contribute to its importance in burn wounds, lung infection and eye infection.
Journal ArticleDOI
Polyphenols as antimicrobial agents
TL;DR: The synergistic effect of polyphenols in combination with conventional antimicrobial agents against clinical multidrug-resistant microorganisms is discussed.