Antimicrobial implications of vitamin D.
Dima Youssef,Christopher W T Miller,Adel El-Abbassi,Della C Cutchins,Coleman Cutchins,William B. Grant,Alan N. Peiris +6 more
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TLDR
The specific antimicrobial properties of vitamin D in combating a wide range of organisms are outlined and the ability to regulate local immune and inflammatory responses offers exciting potential for understanding and treating chronic inflammatory dermatitides is discussed.Abstract:
Evidence exists that vitamin D has a potential antimicrobial activity and its deficiency has deleterious effects on general well-being and longevity. Vitamin D may reduce the risk of infection through multiple mechanisms. Vitamin D boosts innate immunity by modulating production of anti-microbial peptides (AMPs) and cytokine response. Vitamin D and its analogues via these mechanisms are playing an increasing role in the management of atopic dermatitis, psoriasis, vitiligo, acne and rosacea. Vitamin D may reduce susceptibility to infection in patients with atopic dermatitis and the ability to regulate local immune and inflammatory responses offers exciting potential for understanding and treating chronic inflammatory dermatitides. Moreover, B and T cell activation as well as boosting the activity of monocytes and macrophages also contribute to a potent systemic anti-microbial effect. The direct invasion by pathogenic organisms may be minimized at sites such as the respiratory tract by enhancing clearance of invading organisms. A vitamin D replete state appears to benefit most infections, with the possible noteworthy exception of Leishmaniasis. Antibiotics remain an expensive option and misuse of these agents results in significant antibiotic resistance and contributes to escalating health care costs. Vitamin D constitutes an inexpensive prophylactic option and possibly therapeutic product either by itself or as a synergistic agent to traditional antimicrobial agents. This review outlines the specific antimicrobial properties of vitamin D in combating a wide range of organisms. We discuss the possible mechanisms by which vitamin D may have a therapeutic role in managing a variety of infections.read more
Citations
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Journal ArticleDOI
Vitamin D: Update 2013: From rickets prophylaxis to general preventive healthcare.
TL;DR: The results of these studies justify the recommendation to improve the general vitamin D status in children and adults by means of a healthy approach to sunlight exposure, consumption of foods containing vitamin D and supplementation with vitamin D preparations.
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Fat and vitamin intakes during pregnancy have stronger relations with a pro-inflammatory maternal microbiota than does carbohydrate intake
Siddhartha Mandal,Siddhartha Mandal,Keith M. Godfrey,Daniel McDonald,Will Van Treuren,Jørgen Vildershøj Bjørnholt,Jørgen Vildershøj Bjørnholt,Jørgen Vildershøj Bjørnholt,Tore Midtvedt,Birgitte Moen,Knut Rudi,Rob Knight,Anne Lise Brantsæter,Shyamal D. Peddada,Merete Eggesbø +14 more
TL;DR: It is indicated that fats and fat-soluble vitamins are among the most potent dietary modulators of gut microbiota in mothers and the shifts in microbiota due to diet need to be further studied alongside gut microbiota changes during pregnancy to better understand the impact on infant gut microbiota.
Journal ArticleDOI
Is there an association between periprosthetic joint infection and low vitamin D levels
Gerrit Steffen Maier,Konstantin Horas,Jörn Bengt Seeger,Klaus Edgar Roth,Andreas A. Kurth,Uwe Maus +5 more
TL;DR: A high frequency of vitamin D deficiency was found in patients being treated by primary arthroplasty and those with aseptic joint prosthetic loosening and periprosthetic joint infection.
Journal ArticleDOI
Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants.
Merih Cetinkaya,Ferhat Cekmez,G Buyukkale,Tugba Erener-Ercan,Ferhat Demir,Turan Tunc,FN Aydin,Gökhan Aydemir +7 more
TL;DR: Lower maternal and neonatal 25-OHD levels are associated with EOS, and data suggest that adequate vitamin D supplementation during pregnancy may be helpful to prevent EOS in term neonates.
Journal ArticleDOI
Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells
Wei Hu,Lin Zhang,Mingxing Li,Jing Shen,Xiaodong Liu,Zhan Gang Xiao,Ding Lan Wu,Idy H. T. Ho,Justin C.Y. Wu,Cynthia K. Cheung,Yu Chen Zhang,Alaster H. Y. Lau,Hassan Ashktorab,Duane T. Smoot,Evandro Fei Fang,Matthew T. V. Chan,Tony Gin,Wei Gong,William K.K. Wu,Chi Hin Cho +19 more
TL;DR: These findings provide a novel pathogenic mechanism on how H. pylori can survive in the gastric epithelium, and a unique pathway for vitamin D3 to reactivate the autolysosomal degradation function, which is critical for the antibacterial action of Vitamin D3 both in cells and in animals, and perhaps further in humans.
References
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Journal ArticleDOI
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Peck Y. Ong,Takaaki Ohtake,Corinne Brandt,Ian Strickland,Mark Boguniewicz,Tomas Ganz,Richard L. Gallo,Donald Y.M. Leung +7 more
TL;DR: A deficiency in the expression of antimicrobial peptides may account for the susceptibility of patients with atopic dermatitis to skin infection with S. aureus.
Journal ArticleDOI
Cutting Edge: 1,25-dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression
Tian-Tian Wang,Frederick P. Nestel,Véronique Bourdeau,Yoshihiko Nagai,Qiuyu Wang,Jie Liao,Luz E. Tavera-Mendoza,Roberto Lin,John H. Hanrahan,Sylvie Mader,John H. White +10 more
TL;DR: 1,25(OH)2D3 thus directly regulates antimicrobial peptide gene expression, revealing the potential of its analogues in treatment of opportunistic infections.
Journal ArticleDOI
The role of a mutant CCR5 allele in HIV–1 transmission and disease progression
Yaoxing Huang,William A. Paxton,Steven M. Wolinsky,Avidan U. Neumann,Linqi Zhang,Tian He,Stanley Kang,Daniel Ceradini,Zhanqun Jin,Karina Yazdanbakhsh,Kevin J. Kunstman,Daniel L Erickson,Elizabeth A. Dragon,Nathaniel R. Landau,John P. Phair,David D. Ho,Richard A. Koup +16 more
TL;DR: The CCR5 genotype of 1252 homosexual men enrolled in the Chicago component of the Multicenter AIDS Cohort Study (MACS) was analyzed and no evidence was found to suggest that heterozygotes were protected against HIV–1 infection, but a limited protective role against disease progression was noted.
Journal ArticleDOI
Epidemic influenza and vitamin D.
John J. Cannell,Reinhold Vieth,John C. Umhau,Michael F. Holick,William B. Grant,Sasha Madronich,Cedric F. Garland,Edward Giovannucci +7 more
TL;DR: Vitamin D, or lack of it, may be Hope-Simpson's ‘seasonal stimulus’ and dramatically stimulates the expression of potent anti-microbial peptides, which exist in neutrophils, monocytes, natural killer cells, and in epithelial cells lining the respiratory tract where they play a major role in protecting the lung from infection.
Journal ArticleDOI
Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey
TL;DR: Serum 25(OH)D levels are inversely associated with recent URTI, and this association may be stronger in those with respiratory tract diseases.
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