Journal ArticleDOI
Antioxidant status during cutaneous wound healing in immunocompromised rats
TLDR
Significant alterations in the antioxidant profile accompanied by elevated levels of MDA, a marker of free radical damage may be contributory to impaired wound healing in immunocompromised rats.Abstract:
The present investigation was undertaken to investigate the endogenous status of free radical scavengers during cutaneous wound healing in immunocompromised rats. Antioxidant contents and lipid peroxidation product in terms of malondialdehyde (MDA) have been monitored in the wound tissues of immunosuppressed rats at different time intervals (2, 7 and 14 days) following cutaneous injury. A significant increase in MDA content and decrease in glutathione and vitamin C content was observed in the skin of immunocompromised rats as compared to control subjects. Further, a significant decrease in vitamin C, vitamin E content, catalase and glutathione peroxidase activity was observed at 2 days postwounding in immunocompromised rats. A significant and time-dependent decrease in glutathione content was also observed at 7 and 14 days postwounding. However, the healing tissue on 2 and 7 days postwounding exhibited significantly elevated superoxide dismutase activity. The MDA content was augmented only at 2 days postwounding in immunosuppressed rats. Thus significant alterations in the antioxidant profile accompanied by elevated levels of MDA, a marker of free radical damage may be contributory to impaired wound healing in immunocompromised rats.read more
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Oxidative stress in normal and impaired wound repair
Matthias Schäfer,Sabine Werner +1 more
TL;DR: This review summarizes the current information about the roles of low molecular weight antioxidants and ROS-detoxifying enzymes in normal and impaired wound repair, and reports on the consequences of their modulation at the wound site.
Journal Article
Nutritional support for wound healing.
Douglas MacKay,Alan L. Miller +1 more
TL;DR: To promote wound healing in the shortest time possible, with minimal pain, discomfort, and scarring to the patient, it is important to explore nutritional and botanical influences on wound outcome.
Journal ArticleDOI
Selenium and selenoproteins: it's role in regulation of inflammation.
TL;DR: The role of selenium and its possible routes in translational decoding ofselenocysteine, synthesis of seenoproteins, systemic action of seLenoprotein and their indirect assimilation in the process of wound healing are explained in detail.
Journal ArticleDOI
Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats.
TL;DR: The results suggest that O. sanctum has antioxidant properties, which may be responsible and favorable for faster wound healing and this plant extract may be useful in the management of abnormal healing and hypertropic scars.
References
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Journal ArticleDOI
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