Journal ArticleDOI
Apparent Diffusion Coefficient and Beyond: What Diffusion MR Imaging Can Tell Us about Tissue Structure
TLDR
Although apparent diffusion coefficient remains a valid and useful clinical marker, it is clear that more advanced processing of diffusion MR Imaging data is necessary if one wants, someday, diffusion MR imaging to become a “virtual biopsy” tool.Abstract:
Although apparent diffusion coefficient remains a valid and useful clinical marker, it is clear that more advanced processing of diffusion MR imaging data is necessary if one wants, someday, diffusion MR imaging to become a “virtual biopsy” tool.read more
Citations
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Journal ArticleDOI
Clinical Intravoxel Incoherent Motion and Diffusion MR Imaging: Past, Present, and Future.
Mami Iima,Denis Le Bihan +1 more
TL;DR: A review of the clinical literature, mainly focusing on current outstanding issues, is given, followed by some innovative proposals for future improvements.
Journal ArticleDOI
Diffusion kurtosis imaging: an emerging technique for evaluating the microstructural environment of the brain.
TL;DR: Diffusion kurtosis imaging provides independent and complementary information to that acquired with traditional diffusion techniques that may indicate the complexity of the microstructural environment of the imaged tissue and may lead to broad-reaching applications in all aspects of neuroradiology.
Journal ArticleDOI
Body diffusion kurtosis imaging: Basic principles, applications, and considerations for clinical practice
Andrew B. Rosenkrantz,Anwar R. Padhani,Thomas L. Chenevert,Dow-Mu Koh,Frederik De Keyzer,Bachir Taouli,Denis Le Bihan +6 more
TL;DR: A robust understanding ofDKI is necessary for radiologists to better understand the meaning of DKI‐derived metrics in the context of different tumors and how these metrics vary between tumor types and in response to treatment.
Journal ArticleDOI
Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE‐MRI derived biomarkers in multicenter oncology trials
Amita Shukla-Dave,Nancy A. Obuchowski,Thomas L. Chenevert,Sachin Jambawalikar,Lawrence H. Schwartz,Dariya I. Malyarenko,Wei Huang,Susan M. Noworolski,Robert J. Young,Mark S. Shiroishi,Harrison Kim,Catherine Coolens,Hendrik Laue,Caroline Chung,Mark A. Rosen,Michael A. Boss,Edward F. Jackson +16 more
TL;DR: This review focuses on the need for QIBs in oncology applications and emphasizes the importance of the assessment of their reproducibility and repeatability.
Journal ArticleDOI
Diffusion Magnetic Resonance Imaging: What Water Tells Us about Biological Tissues
Denis Le Bihan,Mami Iima +1 more
TL;DR: Since its introduction in the mid-1980s, diffusion magnetic resonance imaging (MRI), which measures the random motion of water molecules in tissues, revealing their microarchitecture, has become a pillar of modern neuroimaging.
References
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Journal ArticleDOI
MR diffusion tensor spectroscopy and imaging.
TL;DR: Once Deff is estimated from a series of NMR pulsed-gradient, spin-echo experiments, a tissue's three orthotropic axes can be determined and the effective diffusivities along these orthotropic directions are the eigenvalues of Deff.
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MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders.
TL;DR: A magnetic resonance (MR) method to image intravoxel incoherent motions (IVIMs) by using appropriate gradient pulses and nonuniform slow flow of cerebrospinal fluid appeared as a useful feature on IVIM images.
Journal ArticleDOI
Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging.
TL;DR: Clinical results showed significant promise of the IVIM method for tissue characterization by perfusion patterns and for functional studies in the evaluation of the microcirculation in physiologic and pathologic conditions, as, for instance, in brain ischemia.
Journal ArticleDOI
Diffusional kurtosis imaging: The quantification of non-gaussian water diffusion by means of magnetic resonance imaging
TL;DR: From the study of six healthy adult subjects, the excess diffusional kurtosis is found to be significantly higher in white matter than in gray matter, reflecting the structural differences between these two types of cerebral tissues.
Journal ArticleDOI
Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system.
Michael E. Moseley,Yoram Cohen,John Kucharczyk,J Mintorovitch,H S Asgari,Michael F. Wendland,Jay S. Tsuruda,David Norman +7 more
TL;DR: The diffusion behavior of intracranial water in the cat brain and spine was examined with the use of diffusion-weighted magnetic resonance (MR) imaging, in which the direction of the diffusion-sensitizing gradient was varied between the x, y, and z axes of the magnet.