Journal ArticleDOI
Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering : a review
TLDR
Some biomaterials, which have been suggested to promote chondrogenesis and to have potentials for tissue engineering of articular cartilage, are reviewed and a new biomaterial, a chitosan-based polysaccharide hydrogel, is introduced and discussed in terms of the biocompatibility with chondrocytes.About:
This article is published in Biomaterials.The article was published on 2000-12-15. It has received 1868 citations till now. The article focuses on the topics: Chondrogenesis & Hyaline cartilage.read more
Citations
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Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L. Drury,David J. Mooney +1 more
TL;DR: Hydrogels are an appealing scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner.
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Biodegradable polymers as biomaterials
TL;DR: This review summarizes the main advances published over the last 15 years, outlining the synthesis, biodegradability and biomedical applications ofBiodegradable synthetic and natural polymers.
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Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology†
TL;DR: This work highlights recent developments in engineering uncrosslinked and crosslinked hydrophilic polymers for biomedical and biological applications and shows how such systems' intelligent behavior can be used in sensors, microarrays, and imaging.
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Chitosan chemistry and pharmaceutical perspectives.
TL;DR: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. S. Nagar, Punjab-160 062, India, Institute of Biochemistry, Faculty of Medicine, Polytechnic University, Via Ranieri 67, IT-60100 Ancona, Italy, and Department of Medicinal Chemistry & Natural Products,The Hebrew University of Jerusalem, School of Pharmacy-Faculty of medicine, Jerusalem 91120, Israel.
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Chitosan—A versatile semi-synthetic polymer in biomedical applications
TL;DR: The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.
References
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Journal ArticleDOI
Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
TL;DR: Cultured autologous chondrocytes can be used to repair deep cartilage defects in the femorotibial articular surface of the knee joint.
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Mesenchymal Cell-Based Repair of Large Full Thickness Defects of Articular Cartilage
Shigeyuki Wakitani,Tatsuhiko Goto,S. Pineda,Randell G. Young,Joseph M. Mansour,Arnold I. Caplan,Victor M. Goldberg +6 more
TL;DR: Osteochondral progenitor cells were used to repair large, full-thickness defects of the articular cartilage that had been created in the knees of rabbits.
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Porous chitosan scaffolds for tissue engineering
TL;DR: The methods and structures described here provide a starting point for the design and fabrication of a family of polysaccharide based scaffold materials with potentially broad applicability in several tissue-relevant geometries.
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Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers
TL;DR: Biocompatibility and toxicity studies suggest that, overall, PLA-PGA biomaterials may be suitable for orthopaedic applications, although certain problems, especially pertaining to reduction in cell proliferation, have been reported.