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Application of support vector machines in viral biology

TLDR
This chapter provides lucid and easy to understand details of SVM algorithms along with applications in virology, one such robust tool based rigorously on statistical learning theory.
Abstract
Novel experimental and sequencing techniques have led to an exponential explosion and spiraling of data in viral genomics. To analyse such data, rapidly gain information, and transform this information to knowledge, interdisciplinary approaches involving several different types of expertise are necessary. Machine learning has been in the forefront of providing models with increasing accuracy due to development of newer paradigms with strong fundamental bases. Support Vector Machines (SVM) is one such robust tool, based rigorously on statistical learning theory. SVM provides very high quality and robust solutions to classification and regression problems. Several studies in virology employ high performance tools including SVM for identification of potentially important gene and protein functions. This is mainly due to the highly beneficial aspects of SVM. In this chapter we briefly provide lucid and easy to understand details of SVM algorithms along with applications in virology.

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Early prediction of developing spontaneous activity in cultured neuronal networks.

TL;DR: In this paper, the authors used machine learning techniques to characterize and predict the developing spontaneous activity in mouse cortical neurons on microelectrode arrays (MEAs) during the first three weeks in vitro.
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Detection of A and B Influenza Viruses by Surface-Enhanced Raman Scattering Spectroscopy and Machine Learning

TL;DR: In this article , the authors demonstrate the possibility of applying surface-enhanced Raman spectroscopy (SERS) combined with machine learning technology to detect and differentiate influenza type A and B viruses in a buffer environment.
Posted ContentDOI

A machine learning based analysis to probe the relationship between odorant structure and olfactory behaviour in C. elegans

TL;DR: In this paper, the authors use olfactory behaviour data from the nematode C. elegans, which has isogenic populations in a laboratory setting, and employ machine learning approaches for a binary classification task predicting whether or not the worm will be attracted to a given monomolecular odorant.
References
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TL;DR: The last sections of this review article focus on PPI experimental approaches and their limitations, and provide an overview of sources of biomolecular data for studying virus–host protein interactions.
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TL;DR: A brief account of the theory and measurement of ROA is given and the ROA spectra of a selection of proteins, nucleic acids, and viruses are presented which illustrate the applications ofROA spectroscopy in biomolecular research.
Journal ArticleDOI

Supervised learning and prediction of physical interactions between human and HIV proteins.

TL;DR: This work presents an application of a supervised learning method for predicting physical interactions between host and pathogen proteins, using the human-HIV system, and uses a classifier trained using features including domain profiles, protein sequence k-mers, and properties of human proteins in a human PPI network.
Journal ArticleDOI

Analysis of dengue infection based on Raman spectroscopy and support vector machine (SVM).

TL;DR: SVM models built on the basis of three different kernel functions including Gaussian radial basis function (RBF), polynomial function and linear function have been employed to classify the human blood sera based on features obtained from Raman Spectra.
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Trending Questions (1)
What are the potential applications of machine learning in virology?

Machine learning, specifically Support Vector Machines (SVM), is used in virology for tasks such as epitope prediction, virus-host interaction detection, and influenza host prediction.