scispace - formally typeset
Open AccessBook ChapterDOI

Application of support vector machines in viral biology

TLDR
This chapter provides lucid and easy to understand details of SVM algorithms along with applications in virology, one such robust tool based rigorously on statistical learning theory.
Abstract
Novel experimental and sequencing techniques have led to an exponential explosion and spiraling of data in viral genomics. To analyse such data, rapidly gain information, and transform this information to knowledge, interdisciplinary approaches involving several different types of expertise are necessary. Machine learning has been in the forefront of providing models with increasing accuracy due to development of newer paradigms with strong fundamental bases. Support Vector Machines (SVM) is one such robust tool, based rigorously on statistical learning theory. SVM provides very high quality and robust solutions to classification and regression problems. Several studies in virology employ high performance tools including SVM for identification of potentially important gene and protein functions. This is mainly due to the highly beneficial aspects of SVM. In this chapter we briefly provide lucid and easy to understand details of SVM algorithms along with applications in virology.

read more

Content maybe subject to copyright    Report

Citations
More filters
Journal ArticleDOI

Early prediction of developing spontaneous activity in cultured neuronal networks.

TL;DR: In this paper, the authors used machine learning techniques to characterize and predict the developing spontaneous activity in mouse cortical neurons on microelectrode arrays (MEAs) during the first three weeks in vitro.
Journal ArticleDOI

Detection of A and B Influenza Viruses by Surface-Enhanced Raman Scattering Spectroscopy and Machine Learning

TL;DR: In this article , the authors demonstrate the possibility of applying surface-enhanced Raman spectroscopy (SERS) combined with machine learning technology to detect and differentiate influenza type A and B viruses in a buffer environment.
Posted ContentDOI

A machine learning based analysis to probe the relationship between odorant structure and olfactory behaviour in C. elegans

TL;DR: In this paper, the authors use olfactory behaviour data from the nematode C. elegans, which has isogenic populations in a laboratory setting, and employ machine learning approaches for a binary classification task predicting whether or not the worm will be attracted to a given monomolecular odorant.
References
More filters
Journal ArticleDOI

A novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks

TL;DR: Computational results suggest that one-class SVM is more suited to be used as negative data sampling method than two-class PPI predictor, and the predictive feedback constrained model selection helps to yield a rational predictive model that reduces the risk of false positive predictions.
Journal ArticleDOI

Characterization of subunit-specific interactions in a double-stranded RNA virus: Raman difference spectroscopy of the phi6 procapsid.

TL;DR: An assembly model is proposed in which P1 induces alpha-helix in P4 during formation of the nucleation complex, and the partially disordered P7 subunit is folded within the context of the procapsid shell.
Journal ArticleDOI

Positive-unlabeled learning for the prediction of conformational B-cell epitopes.

TL;DR: A positive-unlabeled learning algorithm is proposed to distinguish between epitope-likely residues and reliable negative residues in unlabeled data and it is shown that this method outperforms those commonly used predictors DiscoTope 2.0, ElliPro and SEPPA2.0 in every aspect.
Journal ArticleDOI

ViralPhos: incorporating a recursively statistical method to predict phosphorylation sites on virus proteins

TL;DR: A computational method, ViralPhos, is proposed, which aims to investigate virus substrate site motifs and identify potential phosphorylation sites on virus proteins, and is shown to be capable of predicting virus phosphorylated sites.
Journal ArticleDOI

Microarray-based identification of antigenic variants of foot-and-mouth disease virus: a bioinformatics quality assessment

TL;DR: A specific approach based on a microarray platform aimed at distinguishing point mutants within an important determinant of antigenicity and host cell tropism, namely the G-H loop of capsid protein VP1, was developed.
Related Papers (5)
Trending Questions (1)
What are the potential applications of machine learning in virology?

Machine learning, specifically Support Vector Machines (SVM), is used in virology for tasks such as epitope prediction, virus-host interaction detection, and influenza host prediction.