Applications of metabolomics in cancer research.
TLDR
This review summarizes contributions that metabolomics has made in cancer research and presents the current challenges and potential future directions within the field.Abstract:
The first discovery of metabolic changes in cancer occurred almost a century ago. While the genetic underpinnings of cancer have dominated its study since then, altered metabolism has recently been acknowledged as a key hallmark of cancer and metabolism-focused research has received renewed attention. The emerging field of metabolomics - which attempts to profile all metabolites within a cell or biological system - is now being used to analyze cancer metabolism on a system-wide scale, painting a broad picture of the altered pathways and their interactions with each other. While a large fraction of cancer metabolomics research is focused on finding diagnostic biomarkers, metabolomics is also being used to obtain more fundamental mechanistic insight into cancer and carcinogenesis. Applications of metabolomics are also emerging in areas such as tumor staging and assessment of treatment efficacy. This review summarizes contributions that metabolomics has made in cancer research and presents the current challenges and potential future directions within the field.read more
Citations
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Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
Matthew G. Vander Heiden,Matthew G. Vander Heiden,Jason W. Locasale,Jason W. Locasale,Kenneth D. Swanson,Hadar Sharfi,Gregory J. Heffron,Daniel Amador-Noguez,Heather R. Christofk,Gerhard Wagner,Joshua D. Rabinowitz,John M. Asara,Lewis C. Cantley,Lewis C. Cantley +13 more
TL;DR: In this paper, the authors demonstrate that phosphoenolpyruvate (PEP) can act as a phosphate donor in mammalian cells because PEP participates in the phosphorylation of the glycolytic enzyme phosphoglycerate mutase (PGAM1) in PKM2-expressing cells.
Journal ArticleDOI
Emerging field of metabolomics: big promise for cancer biomarker identification and drug discovery.
Seema Patel,Shadab Ahmed +1 more
TL;DR: The authors scoured through the most recent, high-impact papers archived in Pubmed, ScienceDirect, Wiley and Springer databases to compile this review to pique the interest of researchers towards cancer metabolomics.
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Serum metabolomics for early diagnosis of esophageal squamous cell carcinoma by UHPLC-QTOF/MS
Jialin Wang,Jialin Wang,Tao Zhang,Xiaotao Shen,Jia Liu,Jia Liu,Deli Zhao,Yawen Sun,Yawen Sun,Lu Wang,Yingjun Liu,Xiaoyun Gong,Yanxun Liu,Zheng-Jiang Zhu,Fuzhong Xue +14 more
TL;DR: Findings suggest serum metabolomics, performed in a minimally noninvasive and convenient manner, may possess great potential for early diagnosis of ESCC patients.
Journal ArticleDOI
Proteome–Metabolome Profiling of Ovarian Cancer Ascites Reveals Novel Components Involved in Intercellular Communication
Victoria O. Shender,Marat S. Pavlyukov,Rustam H. Ziganshin,Georgij Arapidi,Sergey I. Kovalchuk,Nikolay Anikanov,Ilya Altukhov,Ilya Altukhov,Dmitry G. Alexeev,Dmitry G. Alexeev,Ivan Butenko,Alexey L. Shavarda,Alexey L. Shavarda,Elena Khomyakova,Evgeniy G. Evtushenko,Lev A. Ashrafyan,Irina B. Antonova,Igor N. Kuznetcov,Alexey Y. Gorbachev,Mikhail I. Shakhparonov,Vadim M. Govorun +20 more
TL;DR: The study reveals the specific features of malignant ascites that are associated with its function as a medium of intercellular communication and Identification of spliceosomal proteins and RNAs in an extracellular medium is of particular interest.
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Molecular biomarkers and classification models in the evaluation of the prognosis of colorectal cancer.
TL;DR: Emerging data show that cycloxygenase 2 overexpression is significantly associated with worse outcomes in CRC, and recent studies highlight mi-croRNAs as promising prognostic biomarkers.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Cancer statistics, 2010
TL;DR: The American Cancer Society as mentioned in this paper estimated the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data regarding cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from National Center for Health Statistics.
Journal ArticleDOI
Cancer statistics, 2012
TL;DR: The reduction in overall cancer death rates since 1990 in men and 1991 in women translates to the avoidance of about 1,024,400 deaths from cancer, which can be accelerated by applying existing cancer control knowledge across all segments of the population, with an emphasis on those groups in the lowest socioeconomic bracket.