Book ChapterDOI
Applications of Stereotactic Radiosurgery in Neuro-Oncology
Kunal S. Patel,Paul H. Chapman,Marc R. Bussière,Jay S. Loeffler,Clark C. Chen +4 more
- pp 257-271
TLDR
The foundations, imaging, and applications of radiosurgery in neuro-oncology are discussed in this chapter.Abstract:
Radiosurgery involves the focal administration of conformal ionizing radiation (IR) to a diseased tissue. The conformal nature of the radiation delivered limits injury to surrounding nontarget tissue. The therapeutic window of IR is based on the observation that tumor cells harbor a decreased DNA repair capacity relative to nonneoplastic cells. Therefore, radiosurgery is an important treatment option in neuro-oncology. The foundations, imaging, and applications of radiosurgery in neuro-oncology are discussed in this chapter.read more
Citations
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Book ChapterDOI
Physics and Radiation Dosage Issues in Neuroradiosurgical Treatment of Meningiomas
TL;DR: Radiosurgery is a special therapy technique in which intracranial targets are treated using ionizing radiations, delivering the dose to the lesions and sparing at the same time the surrounding organs at risk.
References
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Journal ArticleDOI
Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
David W. Andrews,Charles B. Scott,Paul W. Sperduto,Adam E. Flanders,Laurie E. Gaspar,Michael C. Schell,Maria Werner-Wasik,W. Demas,J. Ryu,Jean-Paul Bahary,Luis Souhami,Marvin Rotman,Minesh P. Mehta,Walter J. Curran +13 more
TL;DR: WBRT and stereotactic radiosurgery should, therefore, be standard treatment for patients with a single unresectable brain metastasis and considered for Patients with two or three brain metastases.
Journal ArticleDOI
Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial.
Eric L. Chang,Jeffrey S. Wefel,Kenneth R. Hess,Pamela K. Allen,Frederick F. Lang,David G. Kornguth,Rebecca Arbuckle,J. Michael Swint,Almon S. Shiu,Moshe H. Maor,Christina A. Meyers +10 more
TL;DR: Patients treated with SRS plus WBRT were at a greater risk of a significant decline in learning and memory function by 4 months compared with the group that received SRS alone, and patients treatment with a combination of SRS and close clinical monitoring was recommended as the preferred treatment strategy.
Journal ArticleDOI
Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases: A Randomized Controlled Trial
Hidefumi Aoyama,Hiroki Shirato,Masao Tago,Keiichi Nakagawa,Tatsuya Toyoda,Kazuo Hatano,M. Kenjyo,Natsuo Oya,Saeko Hirota,Hiroki Shioura,Etsuo Kunieda,Taisuke Inomata,Kazushige Hayakawa,Norio Katoh,Gen Kobashi +14 more
TL;DR: Compared with SRS alone, the use of W BRT plus SRS did not improve survival for patients with 1 to 4 brain metastases, but intracranial relapse occurred considerably more frequently in those who did not receive WBRT.
Journal ArticleDOI
Adjuvant Whole-Brain Radiotherapy Versus Observation After Radiosurgery or Surgical Resection of One to Three Cerebral Metastases: Results of the EORTC 22952-26001 Study
Martin Kocher,Riccardo Soffietti,Ufuk Abacioglu,Salvador Villà,François Fauchon,Brigitta G. Baumert,L. Fariselli,Tzahala Tzuk-Shina,Rolf-Dieter Kortmann,Christian Carrie,Mohamed Ben Hassel,Mauri Kouri,Egils Valeinis,Dirk van den Berge,Sandra Collette,Laurence Collette,Rolf-Peter Mueller +16 more
TL;DR: After radiosurgery or surgery of a limited number of brain metastases, adjuvant WBRT reduces intracranial relapses and neurologic deaths but fails to improve the duration of functional independence and overall survival.
Journal ArticleDOI
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Samuel F. Bunting,Elsa Callen,Nancy Wong,Hua Tang Chen,Federica Polato,Amanda Gunn,Anne Bothmer,Niklas Feldhahn,Oscar Fernandez-Capetillo,Liu Cao,Xiaoling Xu,Chu-Xia Deng,Toren Finkel,Michel C. Nussenzweig,Michel C. Nussenzweig,Jeremy M. Stark,André Nussenzweig +16 more
TL;DR: It is shown that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chromosome rearrangements by a process dependent on the nonhomologous end-joining (NHEJ) factors 53BP1 and DNA ligase 4, illustrating that HR and NHEJ compete to process DNA breaks that arise during DNA replication.