Journal ArticleDOI
Are cadmium effects on plasma gonadotropins, prolactin, ACTH, GH and TSH levels, dose-dependent?
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TLDR
The data suggest that cadmium differentially affects the secretory mechanisms of the pituitary hormones studied depending on the dose used, and the effects of the metal on prolactin and ACTH are dose-dependent.Abstract:
It is well established that cadmium affects plasma levels of the pituitary hormones studied. However, whether the effects of the metal are dose dependent needs to be clarify. This work was designed to evaluate the possible changes in plasma levels of gonadotropins, prolactin, ACTH, GH and TSH after oral cadmium exposure in adult male rats. Plasma levels of these hormones were measured in adult male rats exposed to cadmium chloride (CdCl2) in the drinking water at the doses of 5, 10, 25, 50 or 100 ppm for one month. The lower dose of cadmium increased plasma prolactin levels and higher doses of the metal (25 or 50 ppm) decreased them. There was a continuous increase of plasma ACTH levels from the lower to 25 ppm dose of CdCl2 and decreased them after to basal values with the highest dose. Plasma GH levels were increased with the dose of cadmium of 10 ppm, although the doses of 5, 25 and 50 ppm decreased them. Plasma LH levels were only reduced with the dose of 50 ppm of CdCl2, whereas those of FSH increased. Plasma TSH levels were increased with the doses of 5, 25 and 100 ppm of CdCl2. Cadmium concentration increased in pituitary with the doses of 125, 50 and 100 ppm of CdCl2. These data suggest that cadmium differentially affects the secretory mechanisms of the pituitary hormones studied depending on the dose used. The effects of the metal on prolactin and ACTH are dose-dependent.read more
Citations
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Journal ArticleDOI
Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction.
TL;DR: In consideration of the data currently available and in light of the potentially serious consequences of environmental Cd2+ exposure to human reproduction, it is proposed that priority should be given to studies dedicated to further elucidating the mechanisms involved.
Journal ArticleDOI
Cadmium and Its Neurotoxic Effects
TL;DR: The available finding indicates the neurotoxic effects of Cd that was associated with both biochemical changes of the cell and functional changes of central nervous system, suggesting that neurot toxic effects may play a role in the systemic toxic effects of the exposure to Cd, particularly the long-term exposure.
Journal ArticleDOI
The Effects of Metals as Endocrine Disruptors
TL;DR: This review reports current knowledge regarding the roles that cadmium (Cd), mercury (Hg), arsenic (As), lead (PB), manganese (Mn), and zinc (Zn) play as endocrine-disrupting chemicals (EDCs).
Journal ArticleDOI
Cadmium-induced testicular injury.
TL;DR: This review critically discusses recent data in the field that have demonstrated the Cd-induced toxicity to the testis is probably the result of interactions of a complex network of causes and sheds lights on potential therapeutic or preventive approaches that can be developed in future studies by blocking or minimizing the destructive effects of Cd to testicular function in men.
Journal ArticleDOI
Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels.
Claire de Burbure,Jean-Pierre Buchet,Ariane Leroyer,Catherine Nisse,Jean-Marie Haguenoer,Antonio Mutti,Zdenek Smerhovsky,Miroslav Cikrt,Małgorzata Trzcinka-Ochocka,Grazyna Razniewska,Marek Jakubowski,Alfred Bernard +11 more
TL;DR: Heavy metals polluting the environment can cause subtle effects on children’s renal and dopaminergic systems without clear evidence of a threshold, which reinforces the need to control and regulate potential sources of contamination by heavy metals.
References
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Journal ArticleDOI
Evaluation of certain food additives and contaminants.
TL;DR: This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives and contaminants, with a view to recommending Acceptable Daily Intakes (ADIs) and tolerable intakes, respectively, and to prepare specifications for the identity and purity of food additives.
Journal ArticleDOI
Effect of cadmium and other metal cations on in vitro Leydig cell testosterone production.
John W. Laskey,P.V. Phelps +1 more
TL;DR: Surprisingly, Cd2+, Co2+, Ni2+, and Zn2+, which caused a depression in hCG- and db-cAMP-stimulated T production, caused significant increases in HCHOL- and PREG- stimulated T production over untreated and similarly stimulated cultures, indicating that these cations may act at multiple sites within the Leydig cell.