Assembly of fibronectin extracellular matrix.
TLDR
The major steps, molecular interactions, and cellular mechanisms involved in assembling FN dimers into fibrillar matrix are described while highlighting important issues and major questions that require further investigation.Abstract:
In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are induced to self-associate and to interact with other ECM proteins to form fibrillar networks. Matrix assembly is usually initiated by ECM glycoproteins binding to cell surface receptors, such as fibronectin (FN) dimers binding to α5β1 integrin. Receptor binding stimulates FN self-association mediated by the N-terminal assembly domain and organizes the actin cytoskeleton to promote cell contractility. FN conformational changes expose additional binding sites that participate in fibril formation and in conversion of fibrils into a stabilized, insoluble form. Once assembled, the FN matrix impacts tissue organization by contributing to the assembly of other ECM proteins. Here, we describe the major steps, molecular interactions, and cellular mechanisms involved in assembling FN dimers into fibrillar matrix while highlighting important issues and major questions that require further investigation.read more
Citations
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Extracellular matrix assembly: a multiscale deconstruction
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Role of Extracellular Matrix in Development and Cancer Progression.
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Plasma and cellular fibronectin: distinct and independent functions during tissue repair
Wing S. To,Kim S. Midwood +1 more
TL;DR: Understanding the mechanisms involved in FN assembly and how these interplay with cellular, fibrotic and immune responses may reveal targets for the future development of therapies to regulate aberrant tissue-repair processes is revealed.
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Directional cell movement through tissues is controlled by exosome secretion
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Fibronectins, Their Fibrillogenesis, and In Vivo Functions
TL;DR: The domain organization of FN including the extra domains and variable region that are controlled by alternative splicing are described and how FN-FN and cell-FN interactions play essential roles in the initiation and progression of matrix assembly is discussed.
References
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