Journal ArticleDOI
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder
Stéphanie Mazza,Jean-Paul Soucy,Paul Gravel,Martin Michaud,Ronald B. Postuma,Jessica Massicotte-Marquez,Anne Décary,Jacques Montplaisir +7 more
TLDR
Perfusional abnormalities in patients with REM behavior disorder were located in the brainstem, striatum, and cortex, which are consistent with the anatomic metabolic profile of Parkinson disease.Abstract:
Objective: To investigate the regional cerebral perfusion in patients with idiopathic REM behavior disorder (RBD) in order to establish the topography of networks involved. Methods: We performed cerebral blood flow evaluation using 99m Tc-Ethylene Cysteinate Dimer (ECD) SPECT on eight patients with polysomnographically confirmed RBD and nine age-matched controls. Comparisons were made using SPM2. Results: We found increased perfusion in the pons and putamen bilaterally and in the right hippocampus. In addition, we observed a decreased perfusion in frontal (Brodmann area [BA] 4, 6, 10, 43, 44, 47 bilaterally and left BA 9, 46) and temporo-parietal (BA 13, 22, 43 bilaterally and left BA 7, 19, 20, 21, 39, 40, 41, 42) cortices. Conclusion: Perfusional abnormalities in patients with REM behavior disorder were located in the brainstem, striatum, and cortex. These abnormalities are consistent with the anatomic metabolic profile of Parkinson disease.read more
Citations
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Journal ArticleDOI
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
B. F. Boeve,M. H. Silber,Clifford B. Saper,Tanis J. Ferman,Dennis W. Dickson,Joseph E. Parisi,Eduardo E. Benarroch,J. E. Ahlskog,Glenn E. Smith,R. C. Caselli,M. Tippman-Peikert,E. J. Olson,Siong-Chi Lin,T. Young,Z. Wszolek,C. H. Schenck,M. W. Mahowald,Pablo R. Castillo,K. Del Tredici,Heiko Braak +19 more
TL;DR: The data suggest that many patients with 'idiopathic' RBD are actually exhibiting an early clinical manifestation of an evolving neurodegenerative disorder, and may be appropriate for future drug therapies that affect synuclein pathophysiology, in which the development of parkinsonism and/or dementia could be delayed or prevented.
Journal ArticleDOI
REM sleep behavior disorder
TL;DR: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep as discussed by the authors.
Journal ArticleDOI
Identifying prodromal Parkinson's disease: Pre-Motor disorders in Parkinson's disease
Ronald B. Postuma,Dag Aarsland,Paolo Barone,David J. Burn,Christopher Hawkes,Wolfgang H. Oertel,Tjalf Ziemssen +6 more
TL;DR: The evidence for the utility of olfaction, RBD, autonomic markers, visual changes, mood disorders, and cognitive loss as markers of prodromal PD and the potential sensitivity and specificity of these markers are summarized.
Journal ArticleDOI
Idiopathic REM sleep behaviour disorder and neurodegeneration - an update.
TL;DR: An update on classic and novel biomarkers of α-synuclein-related neurodegeneration in patients with idiopathic RBD, focusing on advances in imaging and neurophysiological, cognitive, autonomic, tissue-specific and other biomarkers.
References
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Journal ArticleDOI
A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.
TL;DR: Techniques of recording, scoring, and doubtful records are carefully considered, and Recommendations for abbreviations, types of pictorial representation, order of polygraphic tracings are suggested.
Book
Principles and Practice of Sleep Medicine
TL;DR: Part 1: Normal Sleep and Its Variations; Part 2: Abnormal Sleep.
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Functional architecture of basal ganglia circuits: neural substrates of parallel processing
TL;DR: Recent evidence indicating that a parallel functional architecture may also be characteristic of the organization within each individual circuit is discussed, which represents a significant departure from earlier concepts of basal ganglia organization.
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Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
B. F. Boeve,M. H. Silber,Clifford B. Saper,Tanis J. Ferman,Dennis W. Dickson,Joseph E. Parisi,Eduardo E. Benarroch,J. E. Ahlskog,Glenn E. Smith,R. C. Caselli,M. Tippman-Peikert,E. J. Olson,Siong-Chi Lin,T. Young,Z. Wszolek,C. H. Schenck,M. W. Mahowald,Pablo R. Castillo,K. Del Tredici,Heiko Braak +19 more