Association between serum perfluorinated chemicals and thyroid function in U.S. adults: the National Health and Nutrition Examination Survey 2007-2010.
TLDR
Higher serum concentrations of PFOA and PFHxS are associated with total T3, total T4, and free T4 in the U.S. general population, and more studies are warranted to clarify the causal relationship.Abstract:
Context: Perfluorinated chemicals (PFCs) have been widely used in a variety of products worldwide for years. The relationship between serum PFCs and thyroid function has never been addressed in a nationally representative survey. Objectives: The study examined the association between serum PFCs and thyroid function in the general U.S. population. Design and Participants: We selected 1181 subjects (aged >20 years) from a National Health and Nutrition Examination Survey (NHANES) in 2007 through 2008 and 2009 through 2010 to determine the relationship between serum PFCs and thyroid function. Data were adjusted for confounding variables. Results: The geometric means and 95% confidence interval (CI) concentrations of perfluorooctanoate (PFOA), perfluorooctane sulfonate, perfluorononanoic acid, and perfluorohexane sulfonate (PFHxS) were 4.15 (4.02–4.29), 14.2 (13.59–14.86), 1.54 (1.48–1.59), and 2.00 (1.89–2.11) ng/mL, respectively. After weighting for sampling strategy, we determined a 1-U increase in natural ...read more
Citations
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Risk to human health related to the presence of perfluoroalkyl substances in food
Dieter Schrenk,Margherita Bignami,Laurent Bodin,James K. Chipman,Jesús del Mazo,Bettina Grasl-Kraupp,Christer Hogstrand,Laurentius Hoogenboom,Jean-Charles Leblanc,Carlo Nebbia,Elsa Nielsen,Evangelia E. Ntzani,Annette Petersen,Salomon Sand,Christiane Vleminckx,Heather M. Wallace,Lars Barregard,Sandra Ceccatelli,Jean-Pierre Cravedi,Thorhallur I. Halldorsson,Line Småstuen Haug,Niklas Johansson,Helle Katrine Knutsen,Martin Rose,Alain-Claude Roudot,Henk Van Loveren,Günter Vollmer,Karen Mackay,Francesca Riolo,Tanja Schwerdtle +29 more
TL;DR: The CONTAM Panel concluded that parts of the European population exceed this tolerable weekly intake (TWI) of 4.4 ng/kg bw per week, which is of concern, and protects against other potential adverse effects observed in humans.
Journal ArticleDOI
Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food
Helle Katrine Knutsen,Jan Alexander,Lars Barregård,Margherita Bignami,Beat Johannes Brüschweiler,Sandra Ceccatelli,Bruce Cottrill,Michael Dinovi,Lutz Edler,Bettina Grasl-Kraupp,Christer Hogstrand,Laurentius Hoogenboom,Carlo Nebbia,Isabelle P. Oswald,Annette Petersen,Martin Rose,Alain-Claude Roudot,Christiane Vleminckx,Günter Vollmer,Heather M. Wallace,Laurent Bodin,Jean-Pierre Cravedi,Thorhallur I. Halldorsson,Line Småstuen Haug,Niklas Johansson,Henk Van Loveren,Petra Gergelova,Karen Mackay,Sara Levorato,Mathijs van Manen,Tanja Schwerdtle +30 more
TL;DR: For PFOS, the increase in serum total cholesterol in adults, and the decrease in antibody response at vaccination in children were identified as the critical effects and the CONTAM Panel established a tolerable weekly intake (TWI) of 13 ng/kg body weight (bw) per week for PFOS and 6 ng/ kg bw for PFOA.
Journal ArticleDOI
Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects.
TL;DR: Evidence for the role of some PFAS in disrupted thyroid function, kidney disease, and metabolic syndrome is synthesized with an emphasis on the placenta as a critical yet understudied target of PFAS and programming agent of adult disease.
Journal ArticleDOI
Bias from conditioning on live birth in pregnancy cohorts: an illustration based on neurodevelopment in children after prenatal exposure to organic pollutants
TL;DR: A common bias structure (leading to 'live-birth bias') that arises from studying the effects of prenatal exposure to environmental factors on long-term health outcomes among live births only in pregnancy cohorts is illustrated and the need to identify the determinants of pregnancy loss is highlighted.
Journal ArticleDOI
Per- and polyfluoroalkyl substances in human serum and urine samples from a residentially exposed community
Rachel Rogers Worley,Susan McAfee Moore,Bruce C. Tierney,Xiaoyun Ye,Antonia M. Calafat,Sean Campbell,Million B. Woudneh,Jeffrey W. Fisher +7 more
TL;DR: Serum concentrations of some PFAS are decreasing in this residentially exposed community, but remain elevated compared to the U.S. general population.
References
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Journal ArticleDOI
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Christopher Lau,Katherine Anitole,Colette Hodes,David Y. Lai,Andrea Pfahles-Hutchens,Jennifer Seed +5 more
TL;DR: An overview of the recent advances in the toxicology and mode of action for PFAAs, and of the monitoring data now available for the environment, wildlife, and humans is provided.
Journal ArticleDOI
Biological Monitoring of Polyfluoroalkyl Substances: A Review
TL;DR: The pattern of contamination in wildlife varied among species and locations suggesting multiple emission sources and knowledge gaps with respect to the transport, accumulation, biodegradation, temporal/spatial trends and PFS precursors have been identified.
Journal ArticleDOI
Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000.
TL;DR: The apparent reductions in concentrations of PFOS, PFOA, and PFHxS most likely are related to discontinuation in 2002 of industrial production by electrochemical fluorination ofPFOS and related perfluorooctanesulfonyl fluoride compounds.
Journal ArticleDOI
Small Differences in Thyroid Function May Be Important for Body Mass Index and the Occurrence of Obesity in the Population
Nils Knudsen,Peter Laurberg,Lone Banke Rasmussen,Inge Bülow,Hans Perrild,Lars Ovesen,Torben Jørgensen +6 more
TL;DR: The results suggest that thyroid function could be one of several factors acting in concert to determine body weight in a population and even slightly elevated serum TSH levels are associated with an increase in the occurrence of obesity.