Risk to human health related to the presence of perfluoroalkyl substances in food
Dieter Schrenk,Margherita Bignami,Laurent Bodin,James K. Chipman,Jesús del Mazo,Bettina Grasl-Kraupp,Christer Hogstrand,Laurentius Hoogenboom,Jean-Charles Leblanc,Carlo Nebbia,Elsa Nielsen,Evangelia E. Ntzani,Annette Petersen,Salomon Sand,Christiane Vleminckx,Heather M. Wallace,Lars Barregard,Sandra Ceccatelli,Jean-Pierre Cravedi,Thorhallur I. Halldorsson,Line Småstuen Haug,Niklas Johansson,Helle Katrine Knutsen,Martin Rose,Alain-Claude Roudot,Henk Van Loveren,Günter Vollmer,Karen Mackay,Francesca Riolo,Tanja Schwerdtle +29 more
TLDR
The CONTAM Panel concluded that parts of the European population exceed this tolerable weekly intake (TWI) of 4.4 ng/kg bw per week, which is of concern, and protects against other potential adverse effects observed in humans.Citations
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Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research.
Suzanne E. Fenton,Alan M. Ducatman,Alan R. Boobis,Jamie C. DeWitt,Christopher Lau,Carla A. Ng,James S. Smith,Stephen M. Roberts +7 more
TL;DR: The goals of the present review are to assess the state of the science regarding toxicological effects of PFAS and to develop strategies for advancing knowledge on the health effects of this large family of chemicals.
Journal Article
[Commentary on] Serum vaccine antibody concentrations in children exposed to perfluorinated compounds
TL;DR: In this paper, the authors found that increased exposure to perfluorooctane sulfonic acid (PFOS) was associated with reduced humoral immune response to routine childhood immunizations in children aged 5 and 7 years.
Journal Article
Perfluorochemicals: potential sources of and migration from food packaging Part A Chemistry, analysis, control, exposure & risk assessment
TL;DR: Data will be presented on the types of perfluoro chemicals that are used in food packaging and cookware and the migration or potential for migration of these chemicals into foods or food simulating liquids.
The Navigation Guide: Evidence-Based Medicine Meets Environmental Health
TL;DR: Johnson et al. as mentioned in this paper applied the Navigation Guide methodology to determine whether developmental exposure to perfluorooctanoic acid (PFOA) affects fetal growth in humans.
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PFAS Exposure Pathways for Humans and Wildlife: A Synthesis of Current Knowledge and Key Gaps in Understanding.
Amila O. De Silva,James M. Armitage,Thomas A. Bruton,Clifton Dassuncao,Wendy Heiger-Bernays,Xindi C. Hu,Anna Kärrman,Barry C. Kelly,Carla A. Ng,Anna R. Robuck,Mei Sun,Thomas F. Webster,Elsie M. Sunderland +12 more
TL;DR: Total fluorine (TF) measurements complemented by suspect screening using high resolution mass spectrometry are emerging as essential tools for PFAS exposure assessment to better understand contributions from precursor compounds that degrade into terminal perfluoroalkyl acids (PFAA).
References
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Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins
Robert C. Buck,James Franklin,Urs Berger,Jason M. Conder,Ian T. Cousins,Pim de Voogt,Allan Astrup Jensen,Kurunthachalam Kannan,Scott A. Mabury,Stefan P.J. van Leeuwen +9 more
TL;DR: An overview of PFASs detected in the environment, wildlife, and humans, and recommend clear, specific, and descriptive terminology, names, and acronyms for PFAS, can be found in this article.
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Global distribution of perfluorooctane sulfonate in wildlife.
TL;DR: Fish-eating, predatory animals such as mink and bald eagles contained concentrations of PFOS that were greater than the concentrations in their diets, suggesting that PFOS can bioaccumulate to higher trophic levels of the food chain.
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Sources, fate and transport of perfluorocarboxylates.
TL;DR: Transport pathways for PFCAs in the environment were reviewed, and it was concluded that, in addition to atmospheric transport/degradation of precursors, atmospheric and ocean water transport of the PFCA themselves could significantly contribute to their long-range transport.
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Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers.
Geary W. Olsen,Jean M. Burris,David J. Ehresman,John W. Froehlich,Andrew M. Seacat,John L. Butenhoff,Larry R. Zobel +6 more
TL;DR: Humans appear to have a long half-life of serum elimination of PFOS, PFHS, and PFOA, which may be due, in part, to a saturable renal resorption process.
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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Susanna S.T. Lee,Thierry Pineau,John Drago,Eric J. Lee,Jennie W. Owens,Deanna L. Kroetz,Pedro M. Fernández-Salguero,Heiner Westphal,Frank J. Gonzalez +8 more
TL;DR: It is demonstrated that mPPAR alpha is the major isoform required for mediating the pleiotropic response resulting from the actions of peroxisome proliferators.