Association of HbA1c levels with vascular complications and death in patients with type 2 diabetes: evidence of glycaemic thresholds
Sophia Zoungas,Sophia Zoungas,John Chalmers,Toshiharu Ninomiya,Qiang Li,M. E. Cooper,Stephen Colagiuri,Gregory R. Fulcher,B.E. de Galan,B.E. de Galan,Stephen B. Harrap,Pavel Hamet,Simon Heller,Stephen MacMahon,Michel Marre,Neil R Poulter,F. Travert,Anushka Patel,Bruce Neal,Mark Woodward,Mark Woodward +20 more
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TLDR
In patients with type 2 diabetes, HbA1c levels were associated with lower risks of macrovascular events and death down to a threshold of 7.0% and microv vascular events down toA threshold of 6.5%.Abstract:
Aims/hypothesis
There is conflicting evidence regarding appropriate glycaemic targets for patients with type 2 diabetes. Here, we investigate the relationship between HbA1c and the risks of vascular complications and death in such patients.read more
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KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease
Ian H. de Boer,M. Luiza Caramori,Juliana C.N. Chan,Hiddo J.L. Heerspink,Clint Hurst,Kamlesh Khunti,Adrian Liew,Erin D. Michos,Sankar D. Navaneethan,Wasiu A Olowu,Tami Sadusky,Nikhil Tandon,Katherine R. Tuttle,Christoph Wanner,Katy G. Wilkens,Sophia Zoungas,Peter Rossing +16 more
Journal ArticleDOI
Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review.
TL;DR: It is important that all stakeholders continue to look for innovative ways of managing and preventing diabetes, and optimize cost‐effective screening programs within the community to reduce the impact of DR‐related visual loss.
Journal ArticleDOI
Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trials.
Sophia Zoungas,Sophia Zoungas,Hisatomi Arima,Hisatomi Arima,Hertzel C. Gerstein,Rury R. Holman,Mark Woodward,Mark Woodward,Peter D. Reaven,Rodney A. Hayward,Timothy E. Craven,Ruth L. Coleman,John Chalmers +12 more
TL;DR: More intensive glucose control over 5 years reduced both kidney and eye events and the relative risk was reduced by 20% for kidney events and by 13% for eye events, but was not reduced for nerve events.
Journal ArticleDOI
Markers of and Risk Factors for the Development and Progression of Diabetic Kidney Disease
TL;DR: This review summarizes the evidence regarding the prognostic value and benefits of targeting established and novel risk markers for DKD development and progression and suggests that predictive accuracy often may be increased with greater attention to established markers.
References
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Robust Locally Weighted Regression and Smoothing Scatterplots
TL;DR: Robust locally weighted regression as discussed by the authors is a method for smoothing a scatterplot, in which the fitted value at z k is the value of a polynomial fit to the data using weighted least squares, where the weight for (x i, y i ) is large if x i is close to x k and small if it is not.
Journal ArticleDOI
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
Irene M Stratton,Amanda I Adler,H. Andrew W. Neil,David R. Matthews,Susan E. Manley,Carole A. Cull,D R Hadden,Robert C Turner,Rury R. Holman +8 more
TL;DR: In patients with type 2 diabetes the risk of diabetic complications was strongly associated with previous hyperglycaemia, with the lowest risk being in those with HbA1c values in the normal range (<6.0%).
Journal ArticleDOI
Effects of intensive glucose lowering in type 2 diabetes
Hertzel C. Gerstein,Michael Miller,Robert P. Byington,David C. Goff,J. Thomas Bigger,John B. Buse,William C. Cushman,Saul Genuth,Faramarz Ismail-Beigi,Faramarz Ismail-Beigi,Richard H. Grimm,Jeffrey L. Probstfield,Denise G. Simons-Morton,William T. Friedewald +13 more
TL;DR: In this paper, the authors investigated whether intensive therapy to target normal glycated hemoglobin levels would reduce cardiovascular events in patients with type 2 diabetes who had either established cardiovascular disease or additional cardiovascular risk factors.
Journal ArticleDOI
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
Anushka Patel,Stephen MacMahon,John Chalmers,Bruce Neal,Laurent Billot,Mark Woodward,Mark Woodward,Michel Marre,Mark E. Cooper,Paul Glasziou,Paul Glasziou,Diederick E. Grobbee,Pavel Hamet,Stephen B. Harrap,Simon Heller,Lisheng Liu,Giuseppe Mancia,Carl Erik Mogensen,C. Y. Pan,Neil R Poulter,Anthony Rodgers,Bryan Williams,Severine Bompoint,Bastiaan E. de Galan,Bastiaan E. de Galan,Rohina Joshi,F. Travert +26 more
TL;DR: A strategy of intensive glucose control, involving gliclazide (modified release) and other drugs as required, that lowered the glycated hemoglobin value to 6.5% yielded a 10% relative reduction in the combined outcome of major macrovascular and microvascular events, primarily as a consequence of a 21%relative reduction in nephropathy.
Journal ArticleDOI
Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes
William C. Duckworth,Carlos Abraira,Thomas E. Moritz,Domenic J. Reda,Nicholas V. Emanuele,Peter D. Reaven,Franklin J. Zieve,Jennifer B. Marks,Stephen N. Davis,Rodney A. Hayward,Stuart R. Warren,Steven Goldman,Madeline McCarren,Mary Ellen Vitek,William G. Henderson,Grant D. Huang +15 more
TL;DR: Intensive glucose control in patients with poorly controlled type 2 diabetes had no significant effect on the rates of major cardiovascular events, death, or microvascular complications with the exception of progression of albuminuria.
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