Journal ArticleDOI
β-Glucan modulates the lipopolysaccharide-induced innate immune response in rat mammary epithelial cells.
TLDR
Investigation of lipopolysaccharide-induced inflammatory response and related innate immune signaling in primary rat mammary epithelial cells demonstrated that β-glucan activation of Dectin1/Syk attenuated LPS induction of TLR4/MyD88/NF-κB and inhibited the LPS-induced inflammation factors in mammary endothelial cells, thereby providing a possibly protective effect of β- glucan.About:
This article is published in International Immunopharmacology.The article was published on 2013-02-01. It has received 26 citations till now. The article focuses on the topics: Syk & TLR4.read more
Citations
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An insight into anti-inflammatory effects of fungal beta-glucans
TL;DR: It is worthwhile to investigate the anti-inflammatory properties of fungal β-glucans in a separate review, discussing in vitro studies, animal studies and human studies on anti-inflammation effects of funglass, as well as the structure-anti-inflammatory activity relationships.
Journal ArticleDOI
Oral administration of yeast β-glucan ameliorates inflammation and intestinal barrier in dextran sodium sulfate-induced acute colitis
TL;DR: It is suggested that yeast β-glucan improves DSS-induced changes in mucosal inflammatory lesions and the intestinal barrier by inhibiting the expression of inflammatory mediators and enhancing theexpression of tight junction proteins associated with intestinal permeability.
Journal ArticleDOI
Antioxidative and anti-inflammatory effects of high beta-glucan concentration purified aqueous extract from oat in experimental model of LPS-induced chronic enteritis
Dominika Suchecka,Joanna Harasym,Jacek Wilczak,Małgorzata Gajewska,Michał Oczkowski,Sylwia Gudej,Katarzyna Błaszczyk,Dariusz Kamola,Rafał Filip,Joanna Gromadzka-Ostrowska +9 more
TL;DR: In this article, the authors investigated aqueous extract of beta-glucan from oat (purity approx. 75%) with high (G1) and low (G2) molecular weight to verified its anti-inflammatory and antioxidant effects in a model of chronic LPS-induced enteritis.
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. - eScholarship
TL;DR: This article examined the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs) and found that one or more DAP-pairing receptors negatively regulate signaling through TLRs.
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Taurine supplements in high-fat diets improve survival of juvenile Monopterus albus by reducing lipid deposition and intestinal damage
Se-Jun Park,Yong Shi,Lei Zhong,Huan Zhong,Junzhi Zhang,Changbao Che,Guihong Fu,Yi Hu,Kangsen Mai +8 more
TL;DR: High-fat diets induced negative effects in rice field eels, and dietary supplementation with 0.2 or 0.5% taurine can improve growth performance, decrease lipid deposition, enhance antioxidant ability, and maintain intestinal health.
References
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Journal ArticleDOI
Innate Immune Recognition
TL;DR: Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
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Toll-like receptor signalling
Shizuo Akira,Kiyoshi Takeda +1 more
TL;DR: Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
TL;DR: It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).
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Toll-like receptors in innate immunity.
Kiyoshi Takeda,Shizuo Akira +1 more
TL;DR: Toll-like receptors-mediated activation of innate immunity controls not only host defense against pathogens but also immune disorders, and the involvement of TLR-mediated pathways in autoimmune and inflammatory diseases has been proposed.
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Phylogenetic Perspectives in Innate Immunity
TL;DR: In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.