Bacterial strategies of resistance to antimicrobial peptides.
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TLDR
A comparative overview of Gram-positive and Gram-negative bacterial strategies of resistance to various AMPs, such as repulsion or sequestration by bacterial surface structures, alteration of membrane charge or fluidity, degradation and removal by efflux pumps are given.Abstract:
Antimicrobial peptides (AMPs) are a key component of the host's innate immune system, targeting invasive and colonizing bacteria. For successful survival and colonization of the host, bacteria have a series of mechanisms to interfere with AMP activity, and AMP resistance is intimately connected with the virulence potential of bacterial pathogens. In particular, because AMPs are considered as potential novel antimicrobial drugs, it is vital to understand bacterial AMP resistance mechanisms. This review gives a comparative overview of Gram-positive and Gram-negative bacterial strategies of resistance to various AMPs, such as repulsion or sequestration by bacterial surface structures, alteration of membrane charge or fluidity, degradation and removal by efflux pumps.This article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.read more
Citations
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Antimicrobial host defence peptides: functions and clinical potential
TL;DR: The emerging potential to therapeutically harness cationic host defence peptides to treat infectious diseases, chronic inflammatory disorders and wound healing is assessed, highlighting current preclinical studies and clinical trials.
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Antimicrobial peptides: Application informed by evolution
TL;DR: The knowledge of the evolution and diversity of antimicrobial peptides, the rapid pharmacodynamics of which make them promising candidates for translational applications to complement efforts to overcome antibiotic resistance, are reviewed.
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Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds.
TL;DR: Evaluated AMPs for the treatment of bacterial SSTIs and wounds and an overview of the mechanisms of actions of AMPs that contribute to combat skin infections and to improve wound healing, as well as highlighting perspectives for future therapies and which issues remain.
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Reassessing the Host Defense Peptide Landscape
TL;DR: This review critically examined the role of AMPs and HDPs in infectious diseases and inflammation and explored the concept of chemical space as it applies to HDPs and hypothesize that the various functions and activities of this class of molecule exist on independent but overlapping activity landscapes.
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Antimicrobial Peptides: Features, Action, and Their Resistance Mechanisms in Bacteria.
Hoda Moravej,Zahra Moravej,Maryam Yazdanparast,Mohammad Heiat,Ali Mirhosseini,Mehrdad Moosazadeh Moghaddam,Reza Mirnejad +6 more
TL;DR: A closer understanding of bacterial resistance mechanisms may help in developing novel therapeutic approaches for the treatment of infections caused by pathogenic organisms that are successful in developing extensive resistance to AMPs.
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