Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
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TLDR
The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.Abstract:
In recent years, the basement membrane (BM)--a specialized form of extracellular matrix (ECM)--has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues. The BM mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment. The BM is also an important structural and functional component of blood vessels, constituting an extracellular microenvironment sensor for endothelial cells and pericytes. Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies.read more
Citations
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Journal ArticleDOI
Role of the extracellular matrix and its receptors in smooth muscle cell function: implications in vascular development and disease.
TL;DR: By regulating migration, proliferation and apoptosis as well as extracellular matrix synthesis and assembly, proteoglycans, integrins and the dystrophin–glycoprotein complex may be of great importance both during development and in vascular disease.
Journal ArticleDOI
Control of melanoma progression by various matrikines from basement membrane macromolecules.
TL;DR: The biological effects of various peptides, named matrikines, derived from basement membranes (BM) components, such as laminins, proteoglycans or collagens may control tumor progression by regulating the proteolytic cascades leading to cancer cell dissemination and metastasis.
Journal ArticleDOI
Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer
TL;DR: The molecular alterations of metastatic gastric cancer (GC) are reviewed as it reflects a large proportion of GC patients currently seen in clinic and it is hoped that further exploration and understanding of the multistep metastatic cascade will yield novel therapeutic targets that will lead to better patient outcomes.
Journal ArticleDOI
JWA suppresses tumor angiogenesis via Sp1-activated matrix metalloproteinase-2 and its prognostic significance in human gastric cancer
Yansu Chen,Yefei Huang,Yulin Huang,Xiaowei Xia,Jianbing Zhang,Yan Zhou,Yongfei Tan,Song He,Fulin Qiang,Aiping Li,Oluf Dimitri Re,Oluf Dimitri Re,Gang Li,Jianwei Zhou +13 more
TL;DR: JWA was found to inhibit Sp1 activity via an ubiquitin-proteasome-dependent mechanism and to downregulate the expression of the proangiogenic MMP-2, and loss of JWA expression was strongly correlated with increased GC angiogenesis.
Book ChapterDOI
Matrix Metalloproteinases' Role in Tumor Microenvironment.
TL;DR: The aim of the present chapter is to discuss MMPs' contribution to the evolution of cancer cells, their cellular origin, and their influence in the main processes that take place in the TME.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Integrins: versatility, modulation, and signaling in cell adhesion.
Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
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