Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
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TLDR
The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.Abstract:
In recent years, the basement membrane (BM)--a specialized form of extracellular matrix (ECM)--has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues. The BM mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment. The BM is also an important structural and functional component of blood vessels, constituting an extracellular microenvironment sensor for endothelial cells and pericytes. Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies.read more
Citations
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Periostin and tumor-stroma interactions in non-small cell lung cancer
Ulrich Nitsche,Daniela Stangel,Zheng Pan,Anna Melissa Schlitter,I Esposito,Ivonne Regel,Susanne Raulefs,Helmut Friess,Jörg Kleeff,Mert Erkan +9 more
TL;DR: The tumor microenvironment and stroma activation did not prove to be of prognostic relevance for lung cancer, as it has been previously described for pancreatic cancer and other markers of the microenvironment of NSCLC may be of higher prognostic value, pointing towards tumor-type specific effects.
Journal ArticleDOI
Syndecan-1 in mechanosensing of nanotopological cues in engineered materials.
Victoria Le,Jason Lee,Somali Chaterji,Adrianne Spencer,Yen-Liang Liu,Peter Kim,Hsin-Chih Yeh,Deok Ho Kim,Aaron B. Baker +8 more
TL;DR: Findings support that syndecan-1 knockout leads to alterations in mechanosensing of nanotopographical cues through alterations of in rho-associated signaling pathways, cell mechanics and mediators of the Hippo and TGF-β signaling pathways.
Journal ArticleDOI
Endothelial-cell apoptosis induced by cleaved high-molecular-weight kininogen (HKa) is matrix dependent and requires the generation of reactive oxygen species
Danyu Sun,Keith R. McCrae +1 more
TL;DR: A unique role for oxidant stress in mediating the activity of an antiangiogenic polypeptide is demonstrated and the importance of the extracellular matrix in regulating endothelial-cell survival is highlighted.
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Evaluation of recombinant endostatin in the treatment of atherosclerotic plaques and neovascularization in rabbits
TL;DR: Recombinant endostatin is able to inhibit the growth of neovascularization in the atherosclerotic plaque and the development of plaque.
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Tumor vasculature as target for therapeutic intervention.
TL;DR: To fully exploit the therapeutic potential of these drugs, it appears necessary to combine them with conventional anticancer agents, improve their selectivity for tumor vasculature, and develop biomarkers that predict the tumor sensitivity for these vascular strategies.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Integrins: versatility, modulation, and signaling in cell adhesion.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
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