Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
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TLDR
The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.Abstract:
In recent years, the basement membrane (BM)--a specialized form of extracellular matrix (ECM)--has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues. The BM mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment. The BM is also an important structural and functional component of blood vessels, constituting an extracellular microenvironment sensor for endothelial cells and pericytes. Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies.read more
Citations
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Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
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Matrix metalloproteinases and the regulation of tissue remodelling
TL;DR: Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.
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The biology and function of fibroblasts in cancer
TL;DR: Cancer-associated fibroblasts (CAFs) become synthetic machines that produce many different tumour components and have a role in creating extracellular matrix structure and metabolic and immune reprogramming of the tumour microenvironment with an impact on adaptive resistance to chemotherapy.
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Stromal fibroblasts in cancer initiation and progression
TL;DR: It is revealed that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated and this has important therapeutic implications.
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Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
References
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Journal ArticleDOI
Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo.
Jingsong Xu,Dorothy Rodriguez,Eric Petitclerc,Jenny J. Kim,Masanori Hangai,S. Moon Yuen,George E. Davis,Peter C. Brooks +7 more
TL;DR: A novel mechanism by which proteolysis contributes to angiogenesis by exposing hidden regulatory elements within matrix-immobilized collagen type IV is suggested.
Journal ArticleDOI
Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding
Noriko Yamaguchi,Bela Anand-Apte,Margaret S. Lee,Takako Sasaki,Naomi Fukai,Robert Shapiro,Ivo Que,Clemens W.G.M. Löwik,Rupert Timpl,Bjorn R. Olsen +9 more
TL;DR: The results of the migration assays suggest that endostatin causes a block at one or more steps in V EGF‐induced migration, while VEGF in turn can cause a block of the inhibition byendostatin of VEGf‐ induced migration of HUVECs.
Journal ArticleDOI
Interaction of endostatin with integrins implicated in angiogenesis.
Marko Rehn,Tanja Veikkola,Eola Kukk-Valdre,Hitoshi Nakamura,Maritta Ilmonen,Christian R. Lombardo,Taina Pihlajaniemi,Kari Alitalo,Kristiina Vuori +8 more
TL;DR: It is demonstrated that recombinantly produced human endostatin interacts with alpha(5)- and alpha(v)-integrins on the surface of human endothelial cells, and the interaction is of functional significance in vitro, as it is found that immobilizedendostatin supports endothelial cell survival and migration in an integrin-dependent manner.
Journal ArticleDOI
Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by αvβ3 and α5β1 integrins
Akulapalli Sudhakar,Hikaru Sugimoto,Changqing Yang,Julie C. Lively,Michael Zeisberg,Raghu Kalluri +5 more
TL;DR: Collectively, such distinct properties of human tumstatin and human endostatin provide the first insight into their diverse antiangiogenic actions and argue for combining them for targeting tumor angiogenesis.
Journal ArticleDOI
Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth
George D. Kamphaus,Pablo C. Colorado,David J. Panka,Helmut Hopfer,Ramani Ramchandran,Adriana Torre,Yohei Maeshima,James W. Mier,Vikas P. Sukhatme,Raghu Kalluri +9 more
TL;DR: Canstatin is a powerful therapeutic molecule for suppressing angiogenesis and tumor growth and it is demonstrated that apoptosis induced by canstatin was associated with a down-regulation of the anti-apoptotic protein, FLIP.
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