Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
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TLDR
The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.Abstract:
In recent years, the basement membrane (BM)--a specialized form of extracellular matrix (ECM)--has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues. The BM mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment. The BM is also an important structural and functional component of blood vessels, constituting an extracellular microenvironment sensor for endothelial cells and pericytes. Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies.read more
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Book ChapterDOI
Extracellular Matrix and Tissue Regeneration
Yrjö T. Konttinen,Emilia Kaivosoja,Vasily Stegaev,H. Daniel Wagner,Jaakko Levon,Veli-Matti Tiainen,Zygmunt Mackiewicz +6 more
TL;DR: Extracellular matrix (ECM) is a complex interlinked composite of collagenous molecules, non-collagenous molecules and water-rich mucopolysaccharide ground substance as discussed by the authors.
Journal ArticleDOI
TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells
TL;DR: The results show that Ala+TIMP-2 selectively alters the phosphorylation pattern of VEGFR-2 after VEGF-A stimulation and disrupts the downstream activation of PLC-γ, Ca+2 flux, Akt, and eNOS, as well as decreasing cGMP levels.
Journal ArticleDOI
Urokinase type plasminogen activator mediates Interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration.
Jelena Krstic,Hristina Obradović,Aleksandra Jauković,Ivana Okić-Đorđević,Drenka Trivanović,Tamara Kukolj,Slavko Mojsilović,Vesna Ilić,Juan F. Santibanez,Diana Bugarski +9 more
TL;DR: The data suggested that IL-17 may act as chemotropic factor for PB-MSCs by incrementing cell motility and uPA expression during inflammation development, in an uPA-dependent fashion.
Journal ArticleDOI
Sorafenib analogue SC-60 induces apoptosis through the SHP-1/STAT3 pathway and enhances docetaxel cytotoxicity in triple-negative breast cancer cells.
Chunyu Liu,Chunyu Liu,Jung-Chen Su,Jung-Chen Su,Tzu Ting Huang,Pei-Yi Chu,Pei-Yi Chu,Chun Teng Huang,Wan-Lun Wang,Chia-Han Lee,Ka-Yi Lau,Wen-Chun Tsai,Hsiu-Ping Yang,Chung Wai Shiau,Ling-Ming Tseng,Ling-Ming Tseng,Kuen-Feng Chen +16 more
TL;DR: A sorafenib analogue SC‐60, which lacks angiokinase inhibition activity, but acts as a SHP‐1 agonist, displayed a significant antitumor effect in an MDA‐MB‐468 xenograft model by modulating the SHp‐1/STAT3 axis, indicating the anticancer potential ofSC‐60 in TNBC treatment.
Journal ArticleDOI
The role of DJ-1 in the pathogenesis of endometriosis.
Priyanka Rai,Sisinthy Shivaji +1 more
TL;DR: Abnormally high levels of DJ-1 expression may be involved in endometriosis, possibly by stimulating endometrial cell survival, proliferation, migration, and invasion.
References
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Journal ArticleDOI
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Journal ArticleDOI
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TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
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